After the first surprisingly large (1)H DNP enhancements of the water signal in aqueous solutions of nitroxide radicals observed at high magnetic fields, Overhauser DNP is gaining increasing attention for a number of applications now flourishing, showing the potentialities of this mechanism in solution and solid state NMR as well as in MRI. Unexpected Overhauser DNP enhancements in insulating solids were recently measured at 100K, with a magnitude which increases with the applied magnetic field. We recapitulate here the theoretical premises of Overhauser DNP in solution and analyze the effects of the various parameters on the efficacy of the mechanism, underlining the link between the DNP enhancements and the field dependent relaxation properties. Promisingly, more effective DNP enhancements are expected by exploiting the potentialities offered by (13)C detection and the use of supercritical fluids.
Perspectives on DNP-enhanced NMR spectroscopy in solutions
From The DNP-NMR Blog:
Perspectives on DNP-enhanced NMR spectroscopy in solutions
van Bentum, J., et al., Perspectives on DNP-enhanced NMR spectroscopy in solutions. J Magn Reson, 2016. 264: p. 59-67.
http://www.ncbi.nlm.nih.gov/pubmed/26920831
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04-09-2016 03:54 AM
[NMR paper] Para-hydrogen perspectives in hyperpolarized NMR.
Para-hydrogen perspectives in hyperpolarized NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Para-hydrogen perspectives in hyperpolarized NMR.
J Magn Reson. 2013 Oct;235:130-42
Authors: Glöggler S, Colell J, Appelt S
Abstract
The first instance of para-hydrogen induced polarization (PHIP) in an NMR experiment was serendipitously observed in the 1980s while investigating a hydrogenation reaction (Seldler et al., 1983; Bowers and...
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04-23-2014 06:31 PM
[NMR paper] Perspectives in magnetic resonance: NMR in the post-FFT era.
Perspectives in magnetic resonance: NMR in the post-FFT era.
Related Articles Perspectives in magnetic resonance: NMR in the post-FFT era.
J Magn Reson. 2014 Apr;241:60-73
Authors: Hyberts SG, Arthanari H, Robson SA, Wagner G
Abstract
Multi-dimensional NMR spectra have traditionally been processed with the fast Fourier transformation (FFT). The availability of high field instruments, the complexity of spectra of large proteins, the narrow signal dispersion of some unstructured proteins, and the time needed to record the necessary...
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03-25-2014 11:49 AM
[NMR paper] Perspectives in magnetic resonan NMR in the post-FFT era
Perspectives in magnetic resonan NMR in the post-FFT era
Publication date: April 2014
Source:Journal of Magnetic Resonance, Volume 241</br>
Author(s): Sven G. Hyberts , Haribabu Arthanari , Scott A. Robson , Gerhard Wagner</br>
Multi-dimensional NMR spectra have traditionally been processed with the fast Fourier transformation (FFT). The availability of high field instruments, the complexity of spectra of large proteins, the narrow signal dispersion of some unstructured proteins, and the time needed to record the necessary increments in the indirect dimensions to...
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03-22-2014 01:28 AM
Perspectives of hyperpolarized noble gas MRI beyond 3He
From the The DNP-NMR Blog:
Perspectives of hyperpolarized noble gas MRI beyond 3He
Lilburn, D.M.L., G.E. Pavlovskaya, and T. Meersmann, Perspectives of hyperpolarized noble gas MRI beyond 3He. J. Magn. Reson., 2013. 229(0): p. 173-186.
http://www.sciencedirect.com/science/article/pii/S1090780712003588
[BMNRC community] Perspectives on NMR in drug discovery: a technique comes of age
Perspectives on NMR in drug discovery: a technique comes of age
http://www.nature.com/nrd/journal/v7/n9/abs/nrd2606.html
Nature Reviews Drug Discovery 7, 738-745 (September 2008) | doi:10.1038/nrd2606
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Basic facts and perspectives of Overhauser DNP NMR
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