BMNRC community Perspectives on NMR in drug discovery: a technique comes of age

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Researchers Look at Averting Drug Resistance - Drug Discovery & Development <img alt="" height="1" width="1" /> Researchers Look at Averting Drug Resistance Drug Discovery & Development Kern and her team studied the protein using nuclear magnetic resonance spectroscopy, adding a drug mimetic in order to learn how the structure EmrE was designed and how it functioned as it was transportingâ??moving the drug from the inside of the cell ... Researchers Look at Averting Drug Resistance - Drug Discovery & Development More...	nmrlearner	Online News	0	02-02-2012 08:43 PM
3D Proteins: Getting the Big Picture - Drug Discovery & Development 3D Proteins: Getting the Big Picture - Drug Discovery & Development http://nt3.ggpht.com/news/tbn/k64MPYPXLU8xiM/6.jpg Drug Discovery & Development <img alt="" height="1" width="1" /> 3D Proteins: Getting the Big Picture Drug Discovery & Development For decades, with funding from the National Science Foundation (NSF), Hinton has used nuclear magnetic resonance (NMR) to look at protein structure and function. But he wanted to find a way to educate and engage students about his discoveries. ... and more »	nmrlearner	Online News	0	05-10-2011 07:17 PM
[NMR in the fragment-based drug discovery]. . . Tanpakushitsu Kakusan Koso. 2009 Sep;54(12 Suppl):1617-21 Authors: Hanzawa H, Takizawa T	nmrlearner	Journal club	0	01-28-2011 12:50 PM
[NMR paper] NMR-based methods and strategies for drug discovery. NMR-based methods and strategies for drug discovery. Related Articles NMR-based methods and strategies for drug discovery. Chem Soc Rev. 2003 Nov;32(6):365-72 Authors: Salvatella X, Giralt E Nuclear Magnetic Resonance (NMR) spectroscopy has long been a favourite tool of chemists interested in host-guest systems because it permits access to a wealth of information about the molecular recognition reaction. NMR has evolved dramatically in the last 15 years and, in parallel with the development of NMR methods for the determination of protein...	nmrlearner	Journal club	0	11-24-2010 08:16 PM
[NMR paper] NMR in the acceleration of drug discovery. NMR in the acceleration of drug discovery. Related Articles NMR in the acceleration of drug discovery. Curr Opin Drug Discov Devel. 2001 Jul;4(4):479-92 Authors: Sem DS, Pellecchia M The field of NMR spectroscopy has grown beyond expectations from the first historic observation of nuclear magnetic resonance in 1946 by Bloch and Purcell, to the first generation of protein structures 20 years ago, to the present where NMR structures now represent 15 to 20% of those submitted to the Protein Data Bank (PDB). However, the applications of NMR go far...	nmrlearner	Journal club	0	11-19-2010 07:44 PM
[NMR paper] Applications of NMR in drug discovery. Applications of NMR in drug discovery. Related Articles Applications of NMR in drug discovery. Drug Discov Today. 2000 Jun;5(6):230-240 Authors: Roberts GC In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the single most powerful form of spectroscopy in both chemistry and structural biology. The dramatic technical advances over the past 10-15 years, which continue apace, have markedly increased the range of applications for NMR in the study of protein-ligand interactions. These form the basis for its most...	nmrlearner	Journal club	0	11-18-2010 08:15 PM
[NMR paper] Flow NMR spectroscopy in drug discovery. Flow NMR spectroscopy in drug discovery. Related Articles Flow NMR spectroscopy in drug discovery. Curr Opin Drug Discov Devel. 2000 May;3(3):269-74 Authors: Stockman BJ Flow NMR spectroscopy techniques are becoming increasingly utilized in drug discovery and development. LC-NMR has become a routine method to resolve and identify mixture components. It has broad applications in natural products biochemistry, and drug metabolism and toxicology studies. The rapid throughput of direct-injection NMR of biofluids, combinatorial chemistry samples...	nmrlearner	Journal club	0	11-18-2010 08:15 PM
[NMR paper] NMR screening in drug discovery. NMR screening in drug discovery. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR screening in drug discovery. Curr Opin Biotechnol. 1999 Feb;10(1):54-8 Authors: Moore JM NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis...	nmrlearner	Journal club	0	08-21-2010 04:03 PM

« Previous Thread | Next Thread »

Thread Tools	Search this Thread
Show Printable Version Email this Page	Search this Thread: Advanced Search
Display Modes	Rate This Thread
Linear Mode Switch to Hybrid Mode Switch to Threaded Mode	Rate This Thread:

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off