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» Welcome! Welcome, NMR world! Our visitors map. » Log in User Name Remember Me? Not a member yet? Register Now! Password [NMR paper] NMR Studies of Genomic RNA in 3' Untranslated Region Unveil Pseudoknot Structure that Initiates Viral RNA Replication in SARS-CoV-2 Apr 26, 2024 - 5:48 PM - by nmrlearner NMR Studies of Genomic RNA in 3' Untranslated Region Unveil Pseudoknot Structure that Initiates Viral RNA Replication in SARS-CoV-2 In the 3' untranslated region of the SARS-CoV-2 virus RNA genome, genomic RNA replication is initiated in the highly conserved region called 3'PK, containing three stem structures (P1pk, P2, and P5). According to one proposed mechanism, P1pk and distal P2 stems switch their structure to a pseudoknot through base-pairing, thereby initiating transcription by recruiting RNA-dependent RNA polymerase complexed with nonstructural proteins (nsp)7 and nsp8. However, experimental evidence of pseudoknot... More... 0 Replies | 46 Views [NMR paper] NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity Apr 26, 2024 - 5:48 PM - by nmrlearner NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity The DEAD-box RNA helicase (DDX) plays a central role in many aspects of RNA metabolism by remodeling the defined structure of RNA molecules. While a number of structural studies have revealed the atomistic details of the interaction between DDX and RNA ligands, the molecular mechanism of how this molecule unwinds a structured RNA into an unstructured single-stranded RNA (ssRNA) has largely remained elusive. This is due to challenges in structurally characterizing the unwinding intermediate state... More... 0 Replies | 7 Views [NMR paper] Proline Peptide Bond Isomerization in Ubiquitin under Folding and Denaturing Conditions by Pressure-Jump NMR Apr 26, 2024 - 5:48 PM - by nmrlearner Proline Peptide Bond Isomerization in Ubiquitin under Folding and Denaturing Conditions by Pressure-Jump NMR Proline isomerization is widely recognized as a kinetic bottleneck in protein folding, amplified for proteins rich in Pro residues. We introduced repeated hydrostatic pressure jumps between native and pressure-denaturing conditions inside an NMR sample cell to study proline isomerization in the pressure-sensitized L50A ubiquitin mutant. Whereas in two unfolded heptapeptides, X-Pro peptide bonds isomerized ca 1.6-fold faster at 1 bar than at 2.5 kbar, for ubiquitin ca eight-fold faster... More... 0 Replies | 7 Views [NMR paper] NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation Apr 26, 2024 - 4:20 AM - by nmrlearner NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation Guanylate cyclase activating protein-5 (GCAP5) in zebrafish photoreceptors promotes the activation of membrane receptor retinal guanylate cyclase (GC-E). Previously, we showed the R22A mutation in GCAP5 (GCAP5^(R22A)) abolishes dimerization of GCAP5 and activates GC-E by more than 3-fold compared to that of wild-type GCAP5 (GCAP5^(WT)). Here, we present ITC, NMR, and functional analysis of GCAP5^(R22A) to understand how R22A causes a decreased dimerization affinity and increased cyclase... More... 0 Replies | 37 Views Global fold and backbone dynamics of the hepatitis C virus E2 glycoprotein transmembrane domain determined by NMR - ScienceDirect.com Apr 25, 2024 - 4:20 PM - by nmrlearner Global fold and backbone dynamics of the hepatitis C virus E2 glycoprotein transmembrane domain determined by NMR - ScienceDirect.com Global fold and backbone dynamics of the hepatitis C virus E2 glycoprotein transmembrane domain determined by NMR ScienceDirect.com Read here 0 Replies | 14 Views [NMR paper] NMR methods to detect fluoride binding and transport by membrane proteins Apr 25, 2024 - 4:20 PM - by nmrlearner NMR methods to detect fluoride binding and transport by membrane proteins Solid-state nuclear magnetic resonance (NMR) methods can probe the motions of membrane proteins in liposomes at the atomic level, and propel the understanding of biomolecular processes for which static structures cannot provide a satisfactory description. High-resolution crystallography snapshots have provided a structural basis for fluoride channels. NMR is a powerful tool to build upon these snapshots and depict a dynamic picture of fluoride channels in native-like lipid bilayers. In this... More... 0 Replies | 36 Views [NMR paper] Including the Ensemble of Unstructured Conformations in the Analysis of Protein's Native State by High-Pressure NMR Spectroscopy Apr 25, 2024 - 4:15 AM - by nmrlearner Including the Ensemble of Unstructured Conformations in the Analysis of Protein's Native State by High-Pressure NMR Spectroscopy The analysis of pressure induced changes in the chemical shift of proteins allows statements on structural fluctuations proteins exhibit at ambient pressure. The inherent issue of separating general pressure effects from structural related effects on the pressure dependence of chemical shifts has so far been addressed by considering the characteristics of random coil peptides on increasing pressure. In this work, chemically and pressure denatured states of the cold shock protein B from Bacillus... More... 0 Replies | 38 Views [NMR paper] NMR metabolomic modeling of age and lifespan: A multicohort analysis Apr 24, 2024 - 5:58 AM - by nmrlearner NMR metabolomic modeling of age and lifespan: A multicohort analysis Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological age (CA), mortality, and age-related disease. Ninety-eight metabolic variables were measured in blood from nine UK and Finnish cohort studies (N ?31,000 individuals, age range 24-86 years). We used nonlinear... More... 0 Replies | 21 Views Page 1 of 100 1 2 3 11 51 > Last »

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