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Default New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy.

New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy.

Related Articles New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy.

J Mol Biol. 2015 Dec 18;

Authors: Kay LE

Abstract
In the past several decades solution NMR spectroscopy has emerged as a powerful technique for the study of the structure and dynamics of proteins, providing detailed insights into biomolecular function. Herein I provide a summary of two important areas of application, focusing on NMR studies of (i) supra-molecular systems with aggregate molecular masses in the hundreds of kDa and of (ii) sparsely populated and transiently formed protein states that are thermally accessible from populated ground state conformations. The critical role of molecular dynamics in function is emphasized, highlighting the utility of the NMR technique in providing such often elusive information.


PMID: 26707200 [PubMed - as supplied by publisher]



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