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Default 19F-NMR studies of retinol transfer between cellular retinol binding proteins and pho

19F-NMR studies of retinol transfer between cellular retinol binding proteins and phospholipid vesicles.

Related Articles 19F-NMR studies of retinol transfer between cellular retinol binding proteins and phospholipid vesicles.

FEBS Lett. 1997 Feb 3;402(2-3):116-20

Authors: Rong D, Lin CL, d'Avignon DA, Lovey AJ, Rosenberger M, Li E

The cellular retinol binding proteins, CRBP and CRBP II, are implicated in the cellular uptake of retinol and intracellular trafficking of retinol between sites of metabolic processing. 19F-NMR studies of retinol transfer between CRBP and CRBP II and phospholipid vesicles, using either fluorine-labeled ligand or protein, demonstrated that there was significantly more transfer of retinol from CRBP II to lipid vesicles than from CRBP. Differences in how readily protein-bound retinol is released to lipid bilayers may lead to differences in how these two proteins modulate intracellular retinol metabolism.

PMID: 9037178 [PubMed - indexed for MEDLINE]



Source: PubMed
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