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Postdoctoral Position in biomolecular SSNMR spectroscopy in Grenoble (France)
Jul 20, 2011 - 10:24 PM - by nmrlearner
nmrlearner's Avatar Postdoctoral Position in biomolecular SSNMR spectroscopy in Grenoble (France)

The biomolecular NMR group at the Structural Biology Institute (IBS) in
Grenoble is looking for a highly motivated young researcher to join its team as
a post-doctoral researcher on a project funded by the French Research Funding
Agency ANR (project leader Paul Schanda). The project aims at the molecular
level understanding of the function and dynamics of large proteins, as well as
the development of novel solid-state NMR methods for studying dynamics. A
two-year contract is offered.

We are currently studying two biomolecular systems, (i) a large oligomeric
enzymatic assembly of several hundred kDa, and (ii) a membrane protein involved
in the transport of metabolites through membranes. Substrate entry and release,
binding of substrates and cofactors as well as the intrinsic dynamics in these
systems are central to function. We currently develop and apply innovative
solid-state NMR methods to probe protein dynamics in order to relate intrinsic
flexibility to function. We want to reinforce our team with an enthusiastic
postdoctoral researcher with a strong interest in NMR spectroscopy (and the
development thereof) and fundamental aspects of protein function.
The successful candidate will be working on a large enzymatic assembly, using
solid-state NMR methods, complemented by solution-state NMR, as well as on
development of solid-state NMR techniques to address protein dynamics.

Ideally, the successful candidate should have a PhD in chemistry, biochemistry,
biology or physics and experience in solid- or solution-state... [Read More]
0 Replies | 3,487 Views
Postdoc Position
Jul 20, 2011 - 10:24 PM - by nmrlearner
nmrlearner's Avatar Postdoc Position

A 12 months postdoctoral position is opened in the framework of a collaboration between the CNRS/Rhodia joint Research Lab ‘Laboratoire Polymères et Matériaux Avancés’ (LPMA, UMR 5268), Lyon, France, and the CNRS/University Paris-Est Créteil joint Research Lab ‘Institut de Chimie et des Matériaux Paris-Est’ (ICMPE, UMR 7182), Thiais, France. The postdoctoral researcher will develop his/her research activities at ICMPE, Thiais, in the department ‘Systèmes Polymères Complexes’ and will be co-supervised by Cédric Lorthioir (ICMPE) and Paul Sotta (LPMA). Rhodia is a global specialty chemicals manufacturer with 5 multidisciplinary Research & Development Centers worldwide. Lyon is the main Rhodia R&D Center for Europe. CNRS is one of the main governmental research organization in France, involved in all scientific fields.

Partially polar polymers are very sensitive to water. For example a dry semi-crystalline polymer like polyamide (PA) can absorb up to 12 wt% water in saturated humid atmosphere (Relative Humidity = RH 100). The water content drastically affects the glass transition temperature, which may be shifted from 80°C in the dry state down to -10°C in the humid state, and therefore the mechanical and other properties.

The purpose of this work is to combine advanced Solid-State NMR approaches to investigate the molecular dynamics in polyamides. Selective Solid-State NMR experiments, performed as a function of temperature, will allow identifying the specific types of motions corresponding to the various relaxation processes observed in these materials, in the amorphous phase. The mobility and mobility gradients in the amorphous phase located in the vicinity of the crystallites will be characterized by... [Read More]
0 Replies | 3,859 Views
Postdoc
Jul 20, 2011 - 10:24 PM - by nmrlearner
nmrlearner's Avatar Postdoc

Structural studies of Vpx, the accessory protein of the HIV-2

We are looking for a candidate to apply for a 2 years postdoctoral position in
the Laboratory of Biological NMR and Crystallography at the University Paris
Descartes. The project will aim to determine the structure of the Vpx protein
(112 amino acids) and of its complexes with inhibitors identified after
screening of small compound libraries, using high-field multidimensional NMR
and Molecular Modeling. HIV-2 is the second leading cause of AIDS in humans and
we are interested with the Vpx protein that increases the efficiency of
infection by lentivectors of various origins, allows the transport of viral DNA
to the nucleus and promotes the accumulation of retroviral DNA in some cells of
the immune system. Vpx thus allows viral dissemination but its role in the
replication of HIV-2 and its molecular mechanism are still not understood.

The objectives of this project are to understand at the structural and
mechanistic level, how Vpx inhibits cell defenses against viral infection. We
aim to identify partners of Vpx in cells and to elucidate its exact role in
viral dissemination and its role in the replication of HIV-2. Finally, we want
to understand how cellular factors can modulate the early stages of lentiviral
infection. The obtaining the Vpx protein structure, identification of partners
and the study of their complexes will make our contribution to the
understanding of the mechanisms involved in the various... [Read More]
0 Replies | 3,456 Views
Senior Research Fellow in Solid-State NMR
Jul 20, 2011 - 10:11 AM - by nmrlearner
nmrlearner's Avatar Senior Research Fellow in Solid-State NMR

Senior Research Fellow in Solid-State NMR
Department of Physics

£36,862 - £44,016 pa

Fixed Term Contract for 3 Years

You will work together with the Principal Investigators (PIs), the group's existing experimental officer and technical and secretarial support, to provide an optimum environment for carrying out advanced solid-state NMR research in the Warwick Magnetic Resonance Centre, including pushing forward research projects, both together with the PIs and independently.

As well as fulfilling the duties and responsibilities outlined in the further details, you should develop your own research strands, including taking responsibility for driving such projects forward, designing the research, writing papers and procuring external research funding: this can be independently or together with the PIs.

Informal enquiries: John Hanna; e-mail: J.V.Hanna@warwick.ac.uk and Steven Brown; email; S.P.Brown@warwick.ac.uk

Please quote job vacancy reference number 71278-071.

The closing date/time for applications is midnight (British time) at the end of Friday 05 August 2011.

http://www.jobs.ac.uk/job/ACY927/sen...lid-state-nmr/

You must apply using the procedure described below:

... [Read More]
0 Replies | 2,796 Views
Measurement Scientist | The Clorox Company
Jul 08, 2011 - 6:51 AM - by nmrlearner
nmrlearner's Avatar Measurement Scientist | The Clorox Company

US - CA - Pleasanton, Degrees / Majors:Ph.D. Analytical Chemistry, Ph.D. Chemistry, Ph.D. Chemical Engineering, or Ph.D. Biochemistry. Candidates must be qualified based on education and expertise in the area of NMR spect

More...
0 Replies | 3,355 Views
» News Archive
  Title, Username, & Date
Nuclear Magnetic Resonance Research Specialist - Howard Hughes Medical Institute - Waltham, MA, United States
07-06-2011 06:21 PM
Research/Computer Associate
07-05-2011 06:01 PM
Post-doc position in spin physics at ETH Zurich
07-04-2011 05:50 PM
NMR Specialist Genomic Biology
07-04-2011 05:50 PM
Research Fellowship in NMR Technology/DNP NMR
07-04-2011 05:50 PM
Assistant Professor
07-04-2011 05:50 PM
Postdoctoral teaching fellowship in NMR methodology for the study of inorganic materials
07-04-2011 05:50 PM
Postdoctoral Position in Radiology
07-04-2011 05:50 PM
Postdoc Italy
07-04-2011 05:50 PM
Nmr specialist
07-04-2011 05:50 PM
Post-doc at the interface between NMR and EM at CEA Saclay
07-04-2011 05:50 PM
Postdoc Saclay
07-04-2011 05:50 PM
PhD position, Ecole Normale Superieure, Paris
07-04-2011 05:50 PM
Nuclear Magnetic Resonance Research Specialist - Howard Hughes Medical Institute - Waltham, MA, United States
06-30-2011 05:01 AM
Research Scientist | www.bruker-biospin.com
06-24-2011 04:00 AM
Director of Research Instrumentation | University of Nebraska
06-06-2011 12:53 AM
Temp. Research Associate | Vertex Pharmaceuticals
06-03-2011 12:22 PM
Organic/ Polymer Analyical Chemist - Boulder, CO | Lexmark International, Inc.
06-01-2011 11:55 PM
PhD or postdoctoral fellowships, Tuebingen,
06-01-2011 11:50 AM
PhD position, Australia
06-01-2011 11:50 AM
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