BioNMR
NMR aggregator & online community since 2003
BioNMR    
Learn or help to learn NMR - get free NMR books!
 

Go Back   BioNMR > NMR community > NMR research groups
Advanced Search



Jobs Groups Conferences Literature Pulse sequences Software forums Programs Sample preps Web resources BioNMR issues


Webservers
NMR processing:
MDD
NMR assignment:
Backbone:
Autoassign
MARS
UNIO Match
PINE
Side-chains:
UNIO ATNOS-Ascan
NOEs:
UNIO ATNOS-Candid
UNIO Candid
ASDP
Structure from NMR restraints:
Ab initio:
GeNMR
Cyana
XPLOR-NIH
ASDP
UNIO ATNOS-Candid
UNIO Candid
Fragment-based:
BMRB CS-Rosetta
Rosetta-NMR (Robetta)
Template-based:
GeNMR
I-TASSER
Refinement:
Amber
Structure from chemical shifts:
Fragment-based:
WeNMR CS-Rosetta
BMRB CS-Rosetta
Homology-based:
CS23D
Simshift
Torsion angles from chemical shifts:
Preditor
TALOS
Promega- Proline
Secondary structure from chemical shifts:
CSI (via RCI server)
TALOS
MICS caps, β-turns
d2D
PECAN
Flexibility from chemical shifts:
RCI
Interactions from chemical shifts:
HADDOCK
Chemical shifts re-referencing:
Shiftcor
UNIO Shiftinspector
LACS
CheckShift
RefDB
NMR model quality:
NOEs, other restraints:
PROSESS
PSVS
RPF scores
iCing
Chemical shifts:
PROSESS
CheShift2
Vasco
iCing
RDCs:
DC
Anisofit
Pseudocontact shifts:
Anisofit
Protein geomtery:
Resolution-by-Proxy
PROSESS
What-If
iCing
PSVS
MolProbity
SAVES2 or SAVES4
Vadar
Prosa
ProQ
MetaMQAPII
PSQS
Eval123D
STAN
Ramachandran Plot
Rampage
ERRAT
Verify_3D
Harmony
Quality Control Check
NMR spectrum prediction:
FANDAS
MestReS
V-NMR
Flexibility from structure:
Backbone S2
Methyl S2
B-factor
Molecular dynamics:
Gromacs
Amber
Antechamber
Chemical shifts prediction:
From structure:
Shiftx2
Sparta+
Camshift
CH3shift- Methyl
ArShift- Aromatic
ShiftS
Proshift
PPM
CheShift-2- Cα
From sequence:
Shifty
Camcoil
Poulsen_rc_CS
Disordered proteins:
MAXOCC
Format conversion & validation:
CCPN
From NMR-STAR 3.1
Validate NMR-STAR 3.1
NMR sample preparation:
Protein disorder:
DisMeta
Protein solubility:
camLILA
ccSOL
Camfold
camGroEL
Zyggregator
Isotope labeling:
UPLABEL
Solid-state NMR:
sedNMR


Reply
Thread Tools Search this Thread Rating: Thread Rating: 1 votes, 5.00 average. Display Modes
  #1  
Unread 10-31-2010, 07:09 AM
markber's Avatar
Administrator
 
Join Date: Oct 2008
Posts: 1,538
Points: 35,627, Level: 100
Points: 35,627, Level: 100 Points: 35,627, Level: 100 Points: 35,627, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 0%
Activity: 0% Activity: 0% Activity: 0%
Last Achievements
NMR Credits: 1,550
NMR Points: 35,627
Downloads: 17
Uploads: 4
Default David Fushman's NMR group; University of Maryland, College Park; USA

Link to a David Fushman's webpage




Structure, dynamics, and function of biological macromolecules; Intracellular signaling; Ubiquitin signaling system



A copy of David Fushman's research interests from his website:


"""

My primary scientific interest is in understanding the relationship between structure, dynamics, and function in complex molecular systems, like proteins. Our research spans molecular biophysics, nuclear magnetic resonance (NMR), biochemistry, and structural biology: The major focus is on two areas:
(1) structure and dynamics characterization of multidomain systems with the focus on the molecular mechanisms of the ubiquitin signaling system;
(2) development and application of new, robust theoretical and experimental approaches to protein structure and dynamics in order to understand their roles in protein stability and function.
Our research on intracellular signaling is focused on the ubiquitin-proteasome proteolytic system, the principal regulatory mechanism for the turnover of short-lived proteins in eukaryotes. We uncover the structural determinants of the molecular mechanisms involved in the recognition and processing of the ubiquitin signal and allow differently-linked poly-ubiquitin chains to act as distinct cellular signals (see Polyubiquitin chains: polymeric protein signals, by C. Pickart & D. Fushman, Current Opinion in Chemical Biology (2004) 8, 610-616). We have demonstrated that the conformation of poly-ubiquitin chain depends on the linkage, and this provides the mechanism for differential recognition of alternatively linked chains. Our studies focus on the role of the structure and dynamics of poly-ubiquitin signal in its recognition by various receptors.



We are developing new, robust theoretical and experimental approaches to protein structure and dynamics. Our success in answering the challenging questions in protein signaling rests on the improvements in the existing and development of new methodology. We have developed accurate and efficient methods for determining the overall rotational diffusion tensor of a protein from spin-relaxation measurements and for predicting this tensor directly from proteinís structure. We have designed new experimental methods to measure 15N relaxation and the effects of relaxation interference due to cross-correlation between 15N chemical shift anisotropy (CSA) and 1H-15N dipolar interactions. We are developing a comprehensive approach, based on multiple-field measurements, that allows accurate analysis of protein dynamics and accounts for both rotational anisotropy and CSA variability. We have developed methods for structure characterization of multidomain proteins that rely on long-range structural information (diffusion and/or alignment tensors) and provide information on the relative positioning and orientation of the individual domains within a molecule or complex. We have developed new approaches to determine interdomain motions and orientation based on the overall rotational diffusion measurements. We have developed the Virtual NMR Spectrometer, a computer tool for learning/teaching NMR and for accurate prediction of the outcome of modern NMR experiments.
"""
Reply With Quote


Did you find this post helpful? Yes | No

Reply
Similar Threads
Thread Thread Starter Forum Replies Last Post
NMR Director - Pennsylvania State University - University Park, PA, United States
NMR Director - Pennsylvania State University - University Park, PA, United States The Penn State NMR Facility is seeking an enthusiastic Director with significant relevant work experience. Our world-class facility features a Bruker 850 MHz spectrometer capable of liquids, solids, and microimaging; Bruker 500 and 600 MHz spectrometers equipped with cryogenically cooled probes; and a 500 MHz wide bore solids system. Our Director s... More...
nmrlearner Job marketplace 0 10-09-2011 06:15 AM
Vitali Tugarinov's NMR research group; University of Maryland, College Park; USA
http://www.chem.umd.edu/files/chem/images/faculty_bios/vitali.gif Link to the lab website. Research The research in our laboratory focuses on the studies of high-molecular-weight proteins and supra-molecular complexes in solution by NMR techniques. Solution-based techniques allow the studies of proteins at nearly physiological conditions without need for crystallization. Large proteins and supra-molecular complexes are especially challenging objects for NMR applications because of inherently low sensitivity coupled with high complexity of obtained NMR data. Significant progress in...
markber NMR research groups 0 10-30-2010 05:51 AM
University of Maryland School of Medicine receives $7.9 million grant for ... - Eurek
University of Maryland School of Medicine receives $7.9 million grant for ... - EurekAlert (press release) <img alt="" height="1" width="1" /> University of Maryland School of Medicine receives $7.9 million grant for ... EurekAlert (press release) The University of Maryland will be the only academic institution in the United States and one of only two sites in the country to have a 950 MHz NMR ... University of Maryland partnership receives $7.9M from NIH for superconducting ...PhysOrg.com (press release) all 14 news articles &raquo;
nmrlearner Online News 0 08-15-2010 03:21 AM
NMR Spectroscopy for Microbiologists - David Wishart, University of Alberta
David Wishart gives an overview of NMR for his Microbiology class - this could make a good starting point for any biologists new to NMR.
Derek Educational web pages 0 09-12-2008 10:48 PM
Postdoctoral Position - University of Maryland, College Park
Postdoctoral Position University of Maryland Postdoctoral position is available immediately in the group of Dr. Vitali Tugarinov at the Dept. of Chemistry & Biochemistry, University of Maryland, College Park (http://www.chem.umd.edu/faculty/tugarinov/index.html). Candidates should preferably have experience in one or several of the following areas: biomolecular NMR spectroscopy, protein NMR methodology, protein (bio)chemistry, molecular modeling/structure calculations. The dedicated biomolecular NMR facility in the Center of Biomolecular Structure and Organization features two 600...
vitali Job marketplace 0 10-14-2007 01:29 PM


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes Rate This Thread
Rate This Thread:

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On
Trackbacks are Off
Pingbacks are Off
Refbacks are Off



BioNMR advertisements to pay for website hosting and domain registration. Nobody does it for us.



Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2017, Jelsoft Enterprises Ltd.
Copyright, BioNMR.com, 2003-2013
Search Engine Friendly URLs by vBSEO 3.6.0

All times are GMT. The time now is 08:43 PM.


Map