Dynamic nuclear polarization (DNP) is a method for enhancing nuclear magnetic resonance (NMR) signals that has many potential applications in chemistry and medicine. Traditionally, DNP signal enhancement is achieved through the use of exogenous radicals mixed in a solution with the molecules of interest. Here we show that proton DNP signal enhancements can be obtained for solid samples without the use of solvent and exogenous radicals. Radicals are generated primarily on the surface of a solid sample using electrical discharges. These radicals are found suitable for DNP. They are stable under moderate vacuum conditions, yet readily annihilate upon compound dissolution or air exposure. This feature makes them attractive for use in medical applications, where the current variety of radicals used for DNP faces regulatory problems. In addition, this solvent-free method may be found useful for analytical NMR of solid samples which cannot tolerate solvents, such as certain pharmaceutical products.
Endogenous Stable Radicals for Characterization of Thermally Carbonized Porous Silicon by Solid-State Dynamic Nuclear Polarization 13C NMR
From The DNP-NMR Blog:
Endogenous Stable Radicals for Characterization of Thermally Carbonized Porous Silicon by Solid-State Dynamic Nuclear Polarization 13C NMR
Riikonen, J., et al., Endogenous Stable Radicals for Characterization of Thermally Carbonized Porous Silicon by Solid-State Dynamic Nuclear Polarization13C NMR. The Journal of Physical Chemistry C, 2015. 119(33): p. 19272-19278.
http://dx.doi.org/10.1021/acs.jpcc.5b05970
[NMR paper] Photochemically Induced Dynamic Nuclear Polarization Observed by Solid-state NMR in a Uniformly (13)C-isotope Labeled Photosynthetic Reaction Center.
Photochemically Induced Dynamic Nuclear Polarization Observed by Solid-state NMR in a Uniformly (13)C-isotope Labeled Photosynthetic Reaction Center.
Related Articles Photochemically Induced Dynamic Nuclear Polarization Observed by Solid-state NMR in a Uniformly (13)C-isotope Labeled Photosynthetic Reaction Center.
J Phys Chem B. 2015 Jun 25;
Authors: Paul S, Bode BE, Matysik J, Alia A
Abstract
A sample of solubilized and quinone-depleted reaction centers (RC) from the purple bacterium Rhodobacter (R.) sphaeroides wild-type (WT)...
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Dynamic nuclear polarization enhancement of protons and vanadium-51 in the presence of pH-dependent vanadyl radicals
From The DNP-NMR Blog:
Dynamic nuclear polarization enhancement of protons and vanadium-51 in the presence of pH-dependent vanadyl radicals
Perez Linde, A.J., et al., Dynamic nuclear polarization enhancement of protons and vanadium-51 in the presence of pH-dependent vanadyl radicals. Magn Reson Chem, 2015. 53(2): p. 88-92.
http://www.ncbi.nlm.nih.gov/pubmed/25228149
Temperature dependence of high field 13C dynamic nuclear polarization processes with trityl radicals below 35 Kelvin
From The DNP-NMR Blog:
Temperature dependence of high field 13C dynamic nuclear polarization processes with trityl radicals below 35 Kelvin
Walker, S.A., et al., Temperature dependence of high field 13C dynamic nuclear polarization processes with trityl radicals below 35 Kelvin. Phys. Chem. Chem. Phys., 2013.
http://dx.doi.org/10.1039/C3CP51628H
Dynamic nuclear polarization in solid samples by electrical-discharge-induced radicals
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