The active removal of DNA methylation marks is governed by the ten-eleven translocation (TET) family of enzymes (TET1-3), which iteratively oxidize 5-methycytosine (5mC) into 5-hydroxymethycytosine (5hmC), and then 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins are frequently mutated in myeloid malignancies or inactivated in solid tumors. These methylcytosine dioxygenases are ?-ketoglutarate (?KG)-dependent and are, therefore, sensitive to metabolic homeostasis. For example,...
[NMR paper] Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B.
Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B.
ACS Chem Biol. 2017 Nov 17;12(11):2704-2708
Authors: Wan L, Nagata T, Morishita R, Takaori-Kondo A, Katahira M
Abstract
Human APOBEC3B (A3B) deaminates a cytosine into a...
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The Epstein-Barr Virus B-ZIP Protein Zta RecognizesSpecific DNA Sequences Containing 5-Methylcytosine and 5-Hydroxymethylcytosine
The Epstein-Barr Virus B-ZIP Protein Zta RecognizesSpecific DNA Sequences Containing 5-Methylcytosine and 5-Hydroxymethylcytosine
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00741/20171109/images/medium/bi-2017-007418_0008.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00741
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[NMR paper] Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses.
Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses.
Related Articles Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses.
Nat Commun. 2017 Feb 22;8:14523
Authors: Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, Shimada I
Abstract
Heterotrimeric guanine-nucleotide-binding proteins (G proteins) serve as molecular switches in signalling pathways, by coupling the activation of cell surface receptors to intracellular...
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Cholesterol-Dependent Phase-Demixing in Lipid Bilayersas a Switch for the Activity of the Phosphoinositide-Binding CytoskeletalProtein Gelsolin
Cholesterol-Dependent Phase-Demixing in Lipid Bilayersas a Switch for the Activity of the Phosphoinositide-Binding CytoskeletalProtein Gelsolin
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.5b01363/20160609/images/medium/bi-2015-01363n_0006.gif
Biochemistry
DOI: 10.1021/acs.biochem.5b01363
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NMR reveals novel mechanisms of protein activity regulation.
NMR reveals novel mechanisms of protein activity regulation.
NMR reveals novel mechanisms of protein activity regulation.
Protein Sci. 2011 Mar 14;
Authors: Kalodimos CG
NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide site-resolved information about the conformation entropy of binding, as well as about energetically excited...
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[NMR paper] pH-dependent redox activity and fluxionality of the copper site in amicyanin from Thi
pH-dependent redox activity and fluxionality of the copper site in amicyanin from Thiobacillus yersutus as studied by 300- and 600- MHz 1H NMR.
Related Articles pH-dependent redox activity and fluxionality of the copper site in amicyanin from Thiobacillus yersutus as studied by 300- and 600- MHz 1H NMR.
J Biol Chem. 1990 Feb 15;265(5):2768-74
Authors: Lommen A, Canters GW
The kinetics of the deuteronation of one of the copper ligand histidines of the reduced Type I blue-copper protein amicyanin from Thiobacillus versutus was studied as a...
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation
Linear Mode
