NMR paper Structure-guided Design of G Protein-coupled Receptor Polypharmacology

		BioNMR > Educational resources > Journal club
[NMR paper] Structure-guided Design of G Protein-coupled Receptor Polypharmacology

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

View First Unread

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-28-2021, 03:01 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,187

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Structure-guided Design of G Protein-coupled Receptor Polypharmacology

Structure-guided Design of G Protein-coupled Receptor Polypharmacology

Angewandte Chemie International Edition, Accepted Article.

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Receptor Activity Modifying Proteins Have LimitedEffects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-LikeReceptor Stalk Receptor Activity Modifying Proteins Have LimitedEffects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-LikeReceptor Stalk http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b01180/20180207/images/medium/bi-2017-01180k_0008.gif Biochemistry DOI: 10.1021/acs.biochem.7b01180 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/8Z5smrN57aI More...	nmrlearner	Journal club	0	02-08-2018 04:02 AM
Structural Basis for G Protein-Coupled Receptor Activation Structural Basis for G Protein-Coupled Receptor Activation http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00747/20171010/images/medium/bi-2017-00747c_0005.gif Biochemistry DOI: 10.1021/acs.biochem.7b00747 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/AO4DRBB8hkc More...	nmrlearner	Journal club	0	10-10-2017 09:37 PM
[NMR paper] (19)F NMR-Guided Design of Glycomimetic Langerin Ligands. (19)F NMR-Guided Design of Glycomimetic Langerin Ligands. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles (19)F NMR-Guided Design of Glycomimetic Langerin Ligands. ACS Chem Biol. 2016 Sep 16;11(9):2407-13 Authors: Wamhoff EC, Hanske J, Schnirch L, Aretz J, Grube M, Varón Silva D, Rademacher C Abstract C-type lectin receptors (CLRs) play a pivotal role in pathogen defense and immune homeostasis. Langerin, a CLR predominantly expressed on Langerhans...	nmrlearner	Journal club	0	06-27-2017 05:28 PM
[NMR paper] G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. Related Articles G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. Biochem J. 2013 Apr 15;451(2):343 Authors: Ding X, Zhao X, Watts A Abstract	nmrlearner	Journal club	0	03-29-2013 07:52 PM
[NMR paper] G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. Biochem J. 2013 Mar 15;450(3):443-57 Authors: Ding X, Zhao X, Watts A Abstract GPCRs (G-protein-coupled receptors) are versatile signalling molecules at the cell surface and make up the largest and most diverse family of membrane receptors in the human genome. They convert a large variety of extracellular stimuli into...	nmrlearner	Journal club	0	03-01-2013 09:57 PM
3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org 3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org <img alt="" height="1" width="1" /> 3D structure of an unmodified G protein-coupled receptor in its natural habitat Phys.Org Using NMR spectroscopy, the team mapped the arrangement of atoms in a protein called CXCR1, which detects the inflammatory signal interleukin 8 and, through a G protein located inside the cell, triggers a cascade of events that can mobilize immune ... and more » Read here	nmrlearner	Online News	0	11-04-2012 05:53 AM
3D structure of an unmodified G protein-coupled receptor in its natural habitat - Eureka! Science News 3D structure of an unmodified G protein-coupled receptor in its natural habitat - Eureka! Science News <img alt="" height="1" width="1" /> 3D structure of an unmodified G protein-coupled receptor in its natural habitat Eureka! Science News Scientists have determined the three-dimensional structure of a complete, unmodified G-protein-coupled receptor in its native environment: embedded in a membrane in physiological conditions. Using NMR spectroscopy, the team mapped the arrangement of ... and more » Read here	nmrlearner	Online News	0	10-22-2012 09:07 PM
[NMR paper] Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Sac Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Saccharomyces cerevisiae tridecapeptide pheromone receptor. Related Articles Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Saccharomyces cerevisiae tridecapeptide pheromone receptor. Biopolymers. 1998 Nov;46(6):343-57 Authors: Arshava B, Liu SF, Jiang H, Breslav M, Becker JM, Naider F Peptides representing both loop and the sixth transmembrane regions of the alpha-factor receptor of Saccharomyces cerevisiae were synthesized by...	nmrlearner	Journal club	0	11-17-2010 11:15 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off