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Default NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions.

NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions.

Related Articles NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions.

Angew Chem Int Ed Engl. 2013 Sep 20;

Authors: Gil S, Hošek T, Solyom Z, Kümmerle R, Brutscher B, Pierattelli R, Felli IC

Abstract
When approaching physiological conditions, solvent exchange of amide protons in intrinsically disordered proteins (IDPs) is so pronounced that it becomes a key feature to be considered in NMR experiment design. (13) C NMR experiments recover information that is not accessible through amide proton detection, and solvent exchange can be used to increase sensitivity.


PMID: 24115372 [PubMed - as supplied by publisher]



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