Related ArticlesChiral Recognition Studies of ?-(Nonafluoro-tert-butoxy)carboxylic Acids by NMR Spectroscopy.
J Org Chem. 2015 Jun 19;80(12):6267-74
Authors: Nemes A, Csóka T, Béni S, Farkas V, Rábai J, Szabó D
Abstract
Three chiral ?-(nonafluoro-tert-butoxy)carboxylic acids (R)-1, (RS)-2, (R)-3 were synthesized to examine their application as chiral solvating agents with amines. As a model compound, first (S)- and/or (RS)-?-phenylethylamine was used, and their diastereomeric salts were investigated by (1)H and (19)F NMR and ECD spectroscopy. The NMR spectroscopic studies were carried out at room temperature using the slightly polar CDCl3 and apolar C6D6 as solvents in 5 mM and 54 mM concentrations. The difference of the chemical shifts (??) in the diastereomeric complexes is comparable with other, well-known chiral derivatizing and solvating agents (e.g., Mosher's acid, Pirkle's alcohol). Diastereomeric salts of racemic acids (RS)-1 and (RS)-2 with biologically active amines (1R,2S)-ephedrine and (S)-dapoxetine were also investigated by (19)F NMR spectroscopy.
Nuclear overhauser spectroscopy of chiral CHD methylene groups
Nuclear overhauser spectroscopy of chiral CHD methylene groups
Abstract
Nuclear magnetic resonance spectroscopy (NMR) can provide a great deal of information about structure and dynamics of biomolecules. The quality of an NMR structure strongly depends on the number of experimental observables and on their accurate conversion into geometric restraints. When distance restraints are derived from nuclear Overhauser effect spectroscopy (NOESY), stereo-specific assignments of prochiral atoms can contribute significantly to the accuracy of NMR structures...
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11-28-2015 10:23 AM
Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures
From The DNP-NMR Blog:
Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures
Lego, D., et al., Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures. NMR Biomed, 2014. 27(7): p. 810-6.
http://www.ncbi.nlm.nih.gov/pubmed/24812006
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02-16-2015 04:43 PM
Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures
From The DNP-NMR Blog:
Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures
Lego, D., et al., Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures. NMR Biomed, 2014. 27(7): p. 810-6.
http://www.ncbi.nlm.nih.gov/pubmed/24812006
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02-02-2015 09:55 PM
[NMR paper] (2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR.
(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles (2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR.
J Org Chem. 2014 Jun 20;79(12):5880-6
Authors: Tressler CM, Zondlo NJ
Abstract
(2S,4R)- and...
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12-18-2014 11:22 PM
Solvent and H/D Isotope Effects on the Proton TransferPathways in Heteroconjugated Hydrogen-Bonded Phenol-Carboxylic AcidAnions Observed by Combined UV–vis and NMR Spectroscopy
Solvent and H/D Isotope Effects on the Proton TransferPathways in Heteroconjugated Hydrogen-Bonded Phenol-Carboxylic AcidAnions Observed by Combined UV–vis and NMR Spectroscopy
Benjamin Koeppe, Jing Guo, Peter M. Tolstoy, Gleb S. Denisov and Hans-Heinrich Limbach
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja400611x/aop/images/medium/ja-2013-00611x_0015.gif
Journal of the American Chemical Society
DOI: 10.1021/ja400611x
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA...
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05-09-2013 04:04 AM
The Role of Basic Amino Acids in the Molecular Recognition of Hydroxyapatite by Stath
The Role of Basic Amino Acids in the Molecular Recognition of Hydroxyapatite by Statherin using Solid State NMR.
Related Articles The Role of Basic Amino Acids in the Molecular Recognition of Hydroxyapatite by Statherin using Solid State NMR.
Surf Sci. 2010 Aug 15;604(15-16):L39-L42
Authors: Ndao M, Ash JT, Stayton PS, Drobny GP
Organisms use proteins such as statherin to control the growth of hydroxyapatite (HAP), which is the principal component of teeth and bone. Though much emphasis has been placed on the acidic character of these...
Chiral Recognition Studies of ?-(Nonafluoro-tert-butoxy)carboxylic Acids by NMR Spectroscopy.
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