Replacing a particular hydrogen with an iodine atom to create a halogenated insulin analogue maintains the functionality of the glucose-control hormone but makes it act much faster. Nuclear magnetic resonance spectroscopy and X-ray crystallography have been used to investigate the structure.
[NMR paper] 3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.
3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles 3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.
Org Biomol Chem. 2013 Dec 21;11(47):8269-75
Authors: Muñoz-García JC, Solera C, Carrero P, de Paz JL, Angulo J, Nieto PM
Abstract
The motional behaviour of heparin oligosaccharides in solution is...
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07-06-2014 08:28 PM
[NMR paper] Structure-activity studies of lGnRH-III through rational amino acid substitution and NMR conformational studies.
Structure-activity studies of lGnRH-III through rational amino acid substitution and NMR conformational studies.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Structure-activity studies of lGnRH-III through rational amino acid substitution and NMR conformational studies.
Biopolymers. 2012;98(6):525-34
Authors: Pappa EV, Zompra AA, Diamantopoulou Z, Spyranti Z, Pairas G, Lamari FN, Katsoris P, Spyroulias GA, Cordopatis P
Abstract...
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04-18-2013 10:12 PM
Sweet complexity: Sugars and diabetes
Sweet complexity: Sugars and diabetes
http://www.spectroscopynow.com/common/images/thumbnails/13c0510ebe8.jpgNMR spectroscopy has been used to investigate dicarbonyl sugars formed inside the human body from the natural breakdown of the simple sugar, glucose. The implications for understanding the link with diabetes are discussed.
Source: Spectroscopynow.com
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02-03-2013 08:49 AM
Probing Transient HoogsteenHydrogen Bonds in CanonicalDuplex DNA Using NMR Relaxation Dispersion and Single-Atom Substitution
Probing Transient HoogsteenHydrogen Bonds in CanonicalDuplex DNA Using NMR Relaxation Dispersion and Single-Atom Substitution
Evgenia N. Nikolova, Federico L. Gottardo and Hashim M. Al-Hashimi
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja2117816/aop/images/medium/ja-2011-117816_0002.gif
Journal of the American Chemical Society
DOI: 10.1021/ja2117816
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/KUfkJD6mGz8
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02-17-2012 08:50 AM
[NMR paper] Interaction between the type-3 copper protein tyrosinase and the substrate analogue p
Interaction between the type-3 copper protein tyrosinase and the substrate analogue p-nitrophenol studied by NMR.
Related Articles Interaction between the type-3 copper protein tyrosinase and the substrate analogue p-nitrophenol studied by NMR.
J Am Chem Soc. 2005 Jan 19;127(2):567-75
Authors: Tepper AW, Bubacco L, Canters GW
The interaction of the monooxygenating type-3 copper enzyme Tyrosinase (Ty) from Streptomyces antibioticus with its inhibitor p-nitrophenol (pnp) was studied by paramagnetic NMR methods. The pnp binds to oxidized Ty...
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11-24-2010 11:14 PM
[NMR paper] Interaction between an amantadine analogue and the transmembrane portion of the influ
Interaction between an amantadine analogue and the transmembrane portion of the influenza A M2 protein in liposomes probed by 1H NMR spectroscopy of the ligand.
Related Articles Interaction between an amantadine analogue and the transmembrane portion of the influenza A M2 protein in liposomes probed by 1H NMR spectroscopy of the ligand.
J Med Chem. 2004 Sep 23;47(20):4975-8
Authors: Kolocouris A, Hansen RK, Broadhurst RW
1H NMR spectroscopy of a fluoroamantadine ligand was used to probe the pH dependence of binding to the transmembrane peptide...
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11-24-2010 10:01 PM
[NMR paper] Establishing isostructural metal substitution in metalloproteins using 1H NMR, circul
Establishing isostructural metal substitution in metalloproteins using 1H NMR, circular dichroism, and Fourier transform infrared spectroscopy.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Establishing isostructural metal substitution in metalloproteins using 1H NMR, circular dichroism, and Fourier transform infrared spectroscopy.
...
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08-22-2010 03:50 AM
[NMR paper] Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential
Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition.
Related Articles Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition.
Biochemistry. 1991 Jun 4;30(22):5505-15
Authors: Hua QX, Weiss MA
The solution structure and dynamics of human insulin are investigated by 2D 1H NMR spectroscopy in reference to a previously...
Sweet substitution: NMR and insulin analogue
Replacing a particular hydrogen with an iodine atom to create a halogenated insulin analogue maintains the functionality of the glucose-control hormone but makes it act much faster. Nuclear magnetic resonance spectroscopy and X-ray crystallography have been used to investigate the structure.
Linear Mode
