Thread: NMR paper CP-MAS and solution NMR studies of allosteric communication in CA-assemblies of HIV-1
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Default CP-MAS and solution NMR studies of allosteric communication in CA-assemblies of HIV-1
CP-MAS and solution NMR studies of allosteric communication in CA-assemblies of HIV-1

Solution and solid-state NMR spectroscopy are highly complementary techniques for studying structure and dynamics in very high molecular weight systems. Here we have analysed the dynamics of HIV-1 capsid (CA) assemblies in presence of the cofactors IP6 and ATP?S and the host-factor CPSF6 using a combination of solution state and cross polarisation magic angle spinning (CP-MAS) solid-state NMR. In particular, dynamical effects on ns to µs and µs to ms timescales are observed revealing diverse...

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