Thread: NMR paper Probing transient non-native states in amyloid beta fiber elongation by NMR.
View Single Post
  #1  
Unread 04-19-2019, 10:31 AM
nmrlearner's Avatar
nmrlearner nmrlearner is offline
Senior Member
  
Join Date: Jan 2005
Posts: 23,188
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 0
Downloads: 0
Uploads: 0
Default Probing transient non-native states in amyloid beta fiber elongation by NMR.
Probing transient non-native states in amyloid beta fiber elongation by NMR.

Related Articles Probing transient non-native states in amyloid beta fiber elongation by NMR.

Chem Commun (Camb). 2019 Apr 11;55(31):4483-4486

Authors: Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A

Abstract
Using NMR to probe transient binding of A?1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.


PMID: 30917192 [PubMed - indexed for MEDLINE]



More...
Reply With Quote

Did you find this post helpful? Yes | No