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Default Probing transient non-native states in amyloid beta fiber elongation by NMR.

Probing transient non-native states in amyloid beta fiber elongation by NMR.

Related Articles Probing transient non-native states in amyloid beta fiber elongation by NMR.

Chem Commun (Camb). 2019 Apr 11;55(31):4483-4486

Authors: Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A

Abstract
Using NMR to probe transient binding of A?1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.


PMID: 30917192 [PubMed - indexed for MEDLINE]



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