Thread: Question from NMRWiki Q&A forum 2D-NOESY for macromolecules
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Unread 08-25-2016, 05:42 AM
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Default 2D-NOESY for macromolecules
2D-NOESY for macromolecules

Hi, NOESY is very interesting method bet I have a problem. We are working with polymethacryles (MW about 20 000-30 000 g/mol). Noesy spectrum of polymer in good solvent is adequate with good cross-picks. Meanwhile, spectrum of polymer in bad solvent is without cross-picks. I image that intensities of cross-picks of polymer in bad solvent will be bigger in comparison with the spectrum of polymer in good solvent. Size of agglomerates in bad solvent was about 80 nm (by DLS). Concentration of polymer was 5 mg/ml, 1H NMR spectra of polymers were taken on a Brucker 400 AscendTM nuclear magnetic resonance spectrometer (400 MHz) ; mixing time 50, 200 mikros, experiment noesygpphpp



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