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Default Methyl groups as NMR probes for biomolecular interactions.

Methyl groups as NMR probes for biomolecular interactions.

Related Articles Methyl groups as NMR probes for biomolecular interactions.

Curr Opin Struct Biol. 2015 Sep 21;35:60-67

Authors: Wiesner S, Sprangers R

Abstract
Intermolecular interactions are indispensible for biological function. Here we discuss how novel NMR techniques can provide unique insights into the assembly, dynamics and regulation of biomolecular complexes. We focus on applications that exploit the methyl TROSY effect and show that methodological advances and biological insights go hand in hand. We envision that future methyl TROSY applications will continue to provide unique information regarding intermolecular interactions, even for very large eukaryotic protein complexes that are often highly asymmetric.


PMID: 26407236 [PubMed - as supplied by publisher]



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