Thread: NMR paper Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole de
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Default Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole de
Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR.

Related Articles Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR.

J Org Chem. 2003 May 30;68(11):4527-30

Authors: Wagner GK, Kotschenreuther D, Zimmermann W, Laufer SA

The regiospecific synthesis of 2a (Scheme 3), a novel and potent pyridinyl imidazole inhibitor of p38 MAP (mitogen-activated protein) kinase, and the regioselective preparation of its regioisomer 2b (Scheme 4) are described. Chromatographic and spectroscopic data are presented, which in this class of compounds allow the unambiguous identification of regioisomers prepared by a nonregiospecific synthetic strategy. Biological data demonstrating the importance of the correct regiochemistry for inhibition of p38 are given.

PMID: 12762762 [PubMed - indexed for MEDLINE]



Source: PubMed
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