Related ArticlesIdentification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR.
J Org Chem. 2003 May 30;68(11):4527-30
Authors: Wagner GK, Kotschenreuther D, Zimmermann W, Laufer SA
The regiospecific synthesis of 2a (Scheme 3), a novel and potent pyridinyl imidazole inhibitor of p38 MAP (mitogen-activated protein) kinase, and the regioselective preparation of its regioisomer 2b (Scheme 4) are described. Chromatographic and spectroscopic data are presented, which in this class of compounds allow the unambiguous identification of regioisomers prepared by a nonregiospecific synthetic strategy. Biological data demonstrating the importance of the correct regiochemistry for inhibition of p38 are given.
[NMR paper] 1H-NMR measurement of fractional dissociation of imidazole in intact animals.
1H-NMR measurement of fractional dissociation of imidazole in intact animals.
Related Articles 1H-NMR measurement of fractional dissociation of imidazole in intact animals.
Am J Physiol. 1994 Mar;266(3 Pt 2):R1008-15
Authors: Hitzig BM, Perng WC, Burt T, Okunieff P, Johnson DC
The alphastat hypothesis states that intracellular acid-base status is regulated to maintain constancy of the fractional dissociation of intracellular protein and enzyme imidazole-histidine (alpha-imidazole). A major drawback of this theory has been the lack of a means...
Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole de
Linear Mode
