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[NMR paper] Solution NMR structure of cementum protein 1 derived peptide (CEMP1-p1) and its role in the mineralization process
Apr 13, 2023 - 10:58 AM - by nmrlearner
nmrlearner's Avatar Solution NMR structure of cementum protein 1 derived peptide (CEMP1-p1) and its role in the mineralization process

We report the characterization of the three-dimensional structure of the CEMP1-p1 peptide (MGTSSTDSQQAQHRRCSTSN: corresponding to residues 1-20 of the N-terminus of cementum protein 1 (CEMP1)). This peptide imitates the capacity of CEMP1 to stimulate hydroxyapatite crystal nucleation and growth, and promotes the differentiation of periodontal ligament cells into a cementoblastic phenotype. Additionally, in experimental models of critical-sized calvarial defects in Wistar rats, CEMP1-p1 has shown...

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0 Replies | 274 Views
Antcin A, a phytosterol regulates SARS-CoV-2 spike protein ... - Wiley
Apr 12, 2023 - 9:19 AM - by nmrlearner
nmrlearner's Avatar Antcin A, a phytosterol regulates SARS-CoV-2 spike protein ... - Wiley

Antcin A, a phytosterol regulates SARS-CoV-2 spike protein ... Wiley Read here
0 Replies | 258 Views
Accelerating Drug Discovery: The Power of Protein-Small Molecule ... - PharmiWeb.com
Apr 11, 2023 - 8:49 PM - by nmrlearner
nmrlearner's Avatar Accelerating Drug Discovery: The Power of Protein-Small Molecule ... - PharmiWeb.com

Accelerating Drug Discovery: The Power of Protein-Small Molecule ... PharmiWeb.com Read here
0 Replies | 266 Views
[ASAP] Assessing CO2 Capture in Porous Sorbents via Solid-State NMR-Assisted Adsorption Techniques
Apr 11, 2023 - 8:10 AM - by nmrlearner
nmrlearner's Avatar [ASAP] Assessing CO2 Capture in Porous Sorbents via Solid-State NMR-Assisted Adsorption Techniques

Marina Ilkaeva, Ricardo Vieira, Joa?o M. P. Pereira, Mariana Sardo, Ildefonso Marin-Montesinos, and Lui?s Mafra



Journal of the American Chemical Society
DOI: 10.1021/jacs.3c00281



Source: Journal of the American Chemical Society
0 Replies | 299 Views
Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting ... - Nature.com
Apr 11, 2023 - 8:10 AM - by nmrlearner
nmrlearner's Avatar Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting ... - Nature.com

Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting ... Nature.com Read here
0 Replies | 233 Views
[NMR paper] Anle138b interaction in ?-synuclein aggregates by dynamic nuclear polarization NMR
Apr 11, 2023 - 8:10 AM - by nmrlearner
nmrlearner's Avatar Anle138b interaction in ?-synuclein aggregates by dynamic nuclear polarization NMR

Small molecules that bind to oligomeric protein species such as membrane proteins and fibrils are of clinical interest for development of therapeutics and diagnostics. Definition of the binding site at atomic resolution via NMR is often challenging due to low binding stoichiometry of the small molecule. For fibrils and aggregation intermediates grown in the presence of lipids, we report atomic-resolution contacts to the small molecule at sub nm distance via solid-state NMR using dynamic nuclear...

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0 Replies | 222 Views
[NMR paper] Rational design of a genetically encoded NMR zinc sensor
Apr 11, 2023 - 8:10 AM - by nmrlearner
nmrlearner's Avatar Rational design of a genetically encoded NMR zinc sensor

Elucidating the biochemical roles of the essential metal ion, Zn^(2+), motivates detection strategies that are sensitive, selective, quantitative, and minimally invasive in living systems. Fluorescent probes have identified Zn^(2+) in cells but complementary approaches employing nuclear magnetic resonance (NMR) are lacking. Recent studies of maltose binding protein (MBP) using ultrasensitive ^(129)Xe NMR spectroscopy identified a switchable salt bridge which causes slow xenon exchange and...

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0 Replies | 239 Views
Time-resolved NMR probes the dynamics of protein folding - Physics Today
Apr 10, 2023 - 5:46 AM - by nmrlearner
nmrlearner's Avatar Time-resolved NMR probes the dynamics of protein folding - Physics Today

Time-resolved NMR probes the dynamics of protein folding Physics Today Read here
0 Replies | 260 Views
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