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[ASAP] Profiling Enzyme Activity of l-Asparaginase II by NMR-Based Methyl Fingerprinting at Natural Abundance
May 09, 2023 - 12:35 PM - by nmrlearner
nmrlearner's Avatar [ASAP] Profiling Enzyme Activity of l-Asparaginase II by NMR-Based Methyl Fingerprinting at Natural Abundance

Rachayita Nag, Srishti Joshi, Anurag Singh Rathore, and Subhabrata Majumder



Journal of the American Chemical Society
DOI: 10.1021/jacs.3c02154



Source: Journal of the American Chemical Society
0 Replies | 207 Views
Protein-DNA Docking in Drug Discovery: Identifying Small ... - PharmiWeb.com
May 09, 2023 - 12:35 PM - by nmrlearner
nmrlearner's Avatar Protein-DNA Docking in Drug Discovery: Identifying Small ... - PharmiWeb.com

Protein-DNA Docking in Drug Discovery: Identifying Small ... PharmiWeb.com Read here
0 Replies | 128 Views
[ASAP] Disulfide-Bond-Induced Structural Frustration and Dynamic Disorder in a Peroxiredoxin from MAS NMR
May 05, 2023 - 10:31 AM - by nmrlearner
nmrlearner's Avatar [ASAP] Disulfide-Bond-Induced Structural Frustration and Dynamic Disorder in a Peroxiredoxin from MAS NMR

Laura Troussicot, Alicia Vallet, Mikael Molin, Bjo?rn M. Burmann, and Paul Schanda



Journal of the American Chemical Society
DOI: 10.1021/jacs.3c01200



Source: Journal of the American Chemical Society
0 Replies | 415 Views
Ligand and G-protein selectivity in the ?-opioid receptor - Nature.com
May 05, 2023 - 10:31 AM - by nmrlearner
nmrlearner's Avatar Ligand and G-protein selectivity in the ?-opioid receptor - Nature.com

Ligand and G-protein selectivity in the ?-opioid receptor Nature.com Read here
0 Replies | 145 Views
Protein Crystallization Market Research Report 2023-2031 Market ... - The Northwestern Examiner
May 05, 2023 - 10:31 AM - by nmrlearner
nmrlearner's Avatar Protein Crystallization Market Research Report 2023-2031 Market ... - The Northwestern Examiner

Protein Crystallization Market Research Report 2023-2031 Market ... The Northwestern Examiner Read here
0 Replies | 155 Views
[NMR paper] NMR sample optimization and backbone assignment of a stabilized neurotensin receptor
May 05, 2023 - 10:31 AM - by nmrlearner
nmrlearner's Avatar NMR sample optimization and backbone assignment of a stabilized neurotensin receptor

G protein-coupled receptors (GPCRs) are involved in a multitude of cellular signaling cascades and consequently are a prominent target for pharmaceutical drugs. In the past decades, a growing number of high-resolution structures of GPCRs has been solved, providing unprecedented insights into their mode of action. However, knowledge on the dynamical nature of GPCRs is equally important for a better functional understanding, which can be obtained by NMR spectroscopy. Here, we employed a...

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0 Replies | 150 Views
[NMR paper] Disulfide-Bond-Induced Structural Frustration and Dynamic Disorder in a Peroxiredoxin from MAS NMR
May 05, 2023 - 10:31 AM - by nmrlearner
nmrlearner's Avatar Disulfide-Bond-Induced Structural Frustration and Dynamic Disorder in a Peroxiredoxin from MAS NMR

Disulfide bond formation is fundamentally important for protein structure and constitutes a key mechanism by which cells regulate the intracellular oxidation state. Peroxiredoxins (PRDXs) eliminate reactive oxygen species such as hydrogen peroxide through a catalytic cycle of Cys oxidation and reduction. Additionally, upon Cys oxidation PRDXs undergo extensive conformational rearrangements that may underlie their presently structurally poorly defined functions as molecular chaperones....

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0 Replies | 163 Views
[NMR paper] Cholesterol Biases the Conformational Landscape of the Chemokine Receptor CCR3: A MAS SSNMR-Filtered Molecular Dynamics Study
May 04, 2023 - 6:57 AM - by nmrlearner
nmrlearner's Avatar Cholesterol Biases the Conformational Landscape of the Chemokine Receptor CCR3: A MAS SSNMR-Filtered Molecular Dynamics Study

Cholesterol directs the pathway of ligand-induced G protein-coupled receptor (GPCR) signal transduction. The GPCR C-C motif chemokine receptor 3 (CCR3) is the principal chemotactic receptor for eosinophils, with roles in cancer metastasis and autoinflammatory conditions. Recently, we discovered a direct correlation between bilayer cholesterol and increased agonist-triggered CCR3 signal transduction. However, the allosteric molecular mechanism escalating ligand affinity and G protein coupling is...

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0 Replies | 164 Views
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