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» Welcome! Welcome, NMR world! Our visitors map. » Log in User Name Remember Me? Not a member yet? Register Now! Password A de novo protein catalyzes the synthesis of semiconductor quantum ... - pnas.org Jul 20, 2023 - 10:53 PM - by nmrlearner A de novo protein catalyzes the synthesis of semiconductor quantum ... - pnas.org A de novo protein catalyzes the synthesis of semiconductor quantum ... pnas.org Read here 0 Replies | 164 Views Protein–Ligand Interaction Analyses with Nuclear Magnetic Resonance Spectroscopy Enhanced by Dissolution Triplet ... - American Chemical Society Jul 20, 2023 - 6:33 AM - by nmrlearner Protein–Ligand Interaction Analyses with Nuclear Magnetic Resonance Spectroscopy Enhanced by Dissolution Triplet ... American Chemical Society Protein–Ligand Interaction Analyses with Nuclear Magnetic Resonance Spectroscopy Enhanced by Dissolution Triplet ... - American Chemical Society More... 0 Replies | 166 Views [NMR paper] Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery Jul 20, 2023 - 6:33 AM - by nmrlearner Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery High hit rates from initial ligand-observed NMR screening can make it challenging to prioritize which hits to follow up, especially in cases where there are no available crystal structures of these hits bound to the target proteins or other strategies to provide affinity ranking. Here, we report a reproducible, accurate, and versatile quantitative ligand-observed NMR assay, which can determine K(d) values of fragments in the affinity range of low ?M to low mM using transverse relaxation rate... More... 0 Replies | 264 Views How Tau Protein Sticky Filaments Form in the Brain - Technology Networks Jul 19, 2023 - 12:55 PM - by nmrlearner How Tau Protein Sticky Filaments Form in the Brain - Technology Networks How Tau Protein Sticky Filaments Form in the Brain Technology Networks Read here 0 Replies | 207 Views [NMR paper] Mixture-Based Screening of Focused Combinatorial Libraries by NMR: Application to the Antiapoptotic Protein hMcl-1 Jul 19, 2023 - 12:55 PM - by nmrlearner Mixture-Based Screening of Focused Combinatorial Libraries by NMR: Application to the Antiapoptotic Protein hMcl-1 We report on an innovative ligand discovery strategy based on protein NMR-based screening of a combinatorial library of ~125,000 compounds that was arranged in 96 distinct mixtures. Using sensitive solution protein NMR spectroscopy and chemical perturbation-based screening followed by an iterative synthesis, deconvolutions, and optimization strategy, we demonstrate that the approach could be useful in the identification of initial binding molecules for difficult drug targets, such as those... More... 0 Replies | 196 Views [NMR paper] An ECD and NMR/DP4+ Computational Pipeline for Structure Revision and Elucidation of Diphenazine-Based Natural Products Jul 19, 2023 - 12:55 PM - by nmrlearner An ECD and NMR/DP4+ Computational Pipeline for Structure Revision and Elucidation of Diphenazine-Based Natural Products Discovery and structure elucidation of natural products available in infinitesimally small quantities are recognized challenge. This challenge is epitomized by the diphenazine class of molecules that contain three bridged stereocenters, several conformations, ring fusions, and multiple spatially isolated phenols. Because empirical NMR and spatial analyses using ROESY/NOESY were unsuccessful in tackling these challenges, we developed a computational pipeline to determine the relative and absolute... More... 0 Replies | 176 Views Biologists publish new guidelines to facilitate data sharing of research on disordered proteins - Phys.org Jul 18, 2023 - 6:03 AM - by nmrlearner Biologists publish new guidelines to facilitate data sharing of research on disordered proteins - Phys.org Biologists publish new guidelines to facilitate data sharing of research on disordered proteins Phys.org Read here 0 Replies | 211 Views [NMR paper] NMR Relaxation Experiments Probe Monomer-Fibril Interaction and Identify Critical Interacting Residues Responsible for Distinct Tau Fibril Morphologies Jul 18, 2023 - 6:03 AM - by nmrlearner NMR Relaxation Experiments Probe Monomer-Fibril Interaction and Identify Critical Interacting Residues Responsible for Distinct Tau Fibril Morphologies Tau aggregation is governed by secondary processes, a major pathological pathway for tau protein fibril propagation, yet its molecular mechanism remains unknown. This work uses saturation transfer and lifetime line-broadening experiments to identify the critical residues involved in these secondary processes. Distinct residue-specific NMR relaxation parameters were obtained for the truncated three repeat tau construct (K19) in equilibrium with structurally different, self-aggregated (saK19) or... More... 0 Replies | 225 Views Page 72 of 100 « First < 22 62 70 71 72 73 74 82 > Last »

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