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[NMR paper] NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21 |
Aug 09, 2023 - 12:34 PM - by nmrlearner
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NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21
Chemokines are from a family of secreted cytokines that direct the trafficking of immune cells to coordinate immune responses. Chemokines are involved in numerous disease states, including responding to infections, autoimmune disorders, and cancer metastasis. Ther are chemokines, like CCL21, that signal for cellular migration through the activation of G protein-coupled receptors, like CCR7, through interaction with the receptor's extracellular N-terminus, loops, and core of the receptor. CCL21...
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[NMR paper] Solution NMR investigations of integral membrane proteins: Challenges and innovations |
Aug 06, 2023 - 3:39 PM - by nmrlearner
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Solution NMR investigations of integral membrane proteins: Challenges and innovations
Compared to soluble protein counterparts, the understanding of membrane protein stability, solvent interactions, and function are not as well understood. Recent advancements in labeling, expression, and stabilization of membrane proteins have enabled solution nuclear magnetic resonance spectroscopy to investigate membrane protein conformational states, ligand binding, lipid interactions, stability, and folding. This review highlights these advancements and new understandings and provides...
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