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Scientists Uncover Structural Secrets of Key Cancer Protein - SciTechDaily
Nov 07, 2023 - 7:59 AM - by nmrlearner
nmrlearner's Avatar Scientists Uncover Structural Secrets of Key Cancer Protein - SciTechDaily

Scientists Uncover Structural Secrets of Key Cancer Protein SciTechDaily Read here
0 Replies | 143 Views
[NMR paper] Structural Analysis of Proteins from Bacterial Secretion Systems and Their Assemblies by NMR Spectroscopy
Nov 06, 2023 - 7:18 PM - by nmrlearner
nmrlearner's Avatar Structural Analysis of Proteins from Bacterial Secretion Systems and Their Assemblies by NMR Spectroscopy

Bacterial secretion systems are built up from proteins with different physicochemical characteristics, such as highly hydrophobic transmembrane polypeptides, and soluble periplasmic or intracellular domains. A single complex can be composed of more than ten proteins with distinct features, spreading through different cellular compartments. The membrane and multicompartment nature of the proteins, and their large molecular weight make their study challenging. However, information on their...

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0 Replies | 153 Views
[NMR paper] Streamlined Protein-Protein Interface Loop Mimicry
Nov 05, 2023 - 6:10 PM - by nmrlearner
nmrlearner's Avatar Streamlined Protein-Protein Interface Loop Mimicry


Angewandte Chemie International Edition, EarlyView.

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0 Replies | 157 Views
A viral protein targets mitochondria and chloroplasts by subverting ... - American Society for Microbiology
Nov 05, 2023 - 5:44 AM - by nmrlearner
nmrlearner's Avatar A viral protein targets mitochondria and chloroplasts by subverting ... - American Society for Microbiology

A viral protein targets mitochondria and chloroplasts by subverting ... American Society for Microbiology Read here
0 Replies | 207 Views
Solid-state NMR structure determination of a membrane protein in E ... - Science
Nov 02, 2023 - 12:38 PM - by nmrlearner
nmrlearner's Avatar Solid-state NMR structure determination of a membrane protein in E ... - Science

Solid-state NMR structure determination of a membrane protein in E ... Science Read here
0 Replies | 172 Views
Revealing structural secrets of key cancer protein - Mirage News
Nov 02, 2023 - 12:38 PM - by nmrlearner
nmrlearner's Avatar Revealing structural secrets of key cancer protein Mirage News
Revealing structural secrets of key cancer protein - Mirage News
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0 Replies | 222 Views
[NMR paper] Solid-state NMR structure determination of a membrane protein in E. coli cellular inner membrane
Nov 02, 2023 - 12:38 PM - by nmrlearner
nmrlearner's Avatar Solid-state NMR structure determination of a membrane protein in E. coli cellular inner membrane

Structure determination of membrane proteins in native cellular membranes is critical to precisely reveal their structures in physiological conditions. However, it remains challenging for solid-state nuclear magnetic resonance (ssNMR) due to the low sensitivity and high complexity of ssNMR spectra of cellular membranes. Here, we present the structure determination of aquaporin Z (AqpZ) by ssNMR in Escherichia coli inner membranes. To enhance the signal sensitivity of AqpZ, we optimized protein...

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[NMR paper] A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling
Nov 01, 2023 - 3:27 PM - by nmrlearner
nmrlearner's Avatar A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling

GPCRs exhibit a wide range of pharmacological efficacies, yet the molecular mechanisms responsible for the differential efficacies in response to various ligands remain poorly understood. This lack of understanding has hindered the development of a solid foundation for establishing a mathematical model for signaling efficacy. However, recent progress has been made in delineating and quantifying receptor conformational states and associating function with these conformations. This progress has...

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0 Replies | 157 Views
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