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Researchers identify dynamic behavior of key SARS-CoV-2 accessory protein - Phys.org
Nov 29, 2023 - 8:18 PM - by nmrlearner
nmrlearner's Avatar Researchers identify dynamic behavior of key SARS-CoV-2 accessory protein Phys.org
Researchers identify dynamic behavior of key SARS-CoV-2 accessory protein - Phys.org
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0 Replies | 126 Views
Key Covid Accessory Protein's Dynamic Behavior Identified - Mirage News
Nov 29, 2023 - 7:54 AM - by nmrlearner
nmrlearner's Avatar Key Covid Accessory Protein's Dynamic Behavior Identified Mirage News
Key Covid Accessory Protein's Dynamic Behavior Identified - Mirage News
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0 Replies | 136 Views
[NMR paper] Combined NMR and molecular dynamics conformational filter identifies unambiguously dynamic ensembles of Dengue protease NS2B/NS3pro
Nov 28, 2023 - 4:49 AM - by nmrlearner
nmrlearner's Avatar Combined NMR and molecular dynamics conformational filter identifies unambiguously dynamic ensembles of Dengue protease NS2B/NS3pro

The dengue protease NS2B/NS3pro has been reported to adopt either an 'open' or a 'closed' conformation. We have developed a conformational filter that combines NMR with MD simulations to identify conformational ensembles that dominate in solution. Experimental values derived from relaxation parameters for the backbone and methyl side chains were compared with the corresponding back-calculated relaxation parameters of different conformational ensembles obtained from free MD simulations. Our...

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0 Replies | 290 Views
[NMR paper] Relaxation-Assisted Magnetization Transfer Phenomena for a Sensitivity-Enhanced 2D NMR
Nov 27, 2023 - 1:27 PM - by nmrlearner
nmrlearner's Avatar Relaxation-Assisted Magnetization Transfer Phenomena for a Sensitivity-Enhanced 2D NMR

2D NOESY and TOCSY play central roles in contemporary NMR. We have recently discussed how solvent-driven exchanges can significantly enhance the sensitivity of such methods when attempting correlations between labile and nonlabile protons. This study explores two scenarios where similar sensitivity enhancements can be achieved in the absence of solvent exchange: the first one involves biomolecular paramagnetic systems, while the other involves small organic molecules in natural abundance. It is...

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0 Replies | 180 Views
[NMR paper] Study on the acute toxicity of trichlorfon and its breakdown product dichlorvos to goldfish (Carassius auratus) based on 1H NMR metabonomics
Nov 26, 2023 - 2:01 AM - by nmrlearner
nmrlearner's Avatar Study on the acute toxicity of trichlorfon and its breakdown product dichlorvos to goldfish (Carassius auratus) based on 1H NMR metabonomics

Trichlorfon, one of the most widely used organophosphate insecticides, is commonly employed in aquaculture and agriculture to combat parasitic infestations. However, its inherent instability leads to rapid decomposition into dichlorvos (DDVP), increasing its toxicity by eightfold. Therefore, the environmental effects of trichlorfon in real-world scenarios involve the combined effects of trichlorfon and its degradation product, DDVP. In this study, we systematically investigated the degradation...

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0 Replies | 255 Views
Kanazawa University research: Researchers fix the chirality of helical proteins - Benzinga
Nov 25, 2023 - 1:32 PM - by nmrlearner
nmrlearner's Avatar Kanazawa University research: Researchers fix the chirality of helical proteins - Benzinga

Kanazawa University research: Researchers fix the chirality of helical proteins Benzinga Read here
0 Replies | 109 Views
New way of machining tiny diamond rotors could improve protein studies - Phys.org
Nov 25, 2023 - 1:32 PM - by nmrlearner
nmrlearner's Avatar New way of machining tiny diamond rotors could improve protein studies - Phys.org

New way of machining tiny diamond rotors could improve protein studies Phys.org Read here
0 Replies | 108 Views
Solanum lycopersicum heme-binding protein 2 as a potent ... - Nature.com
Nov 24, 2023 - 11:06 PM - by nmrlearner
nmrlearner's Avatar Solanum lycopersicum heme-binding protein 2 as a potent ... - Nature.com

Solanum lycopersicum heme-binding protein 2 as a potent ... Nature.com Read here
0 Replies | 116 Views
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