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Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy - sciencedirect.com
Feb 18, 2024 - 12:10 AM - by nmrlearner
nmrlearner's Avatar Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy - sciencedirect.com

Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy sciencedirect.com Read here
0 Replies | 58 Views
Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand ... - Nature.com
Feb 18, 2024 - 12:10 AM - by nmrlearner
nmrlearner's Avatar Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand ... - Nature.com

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand ... Nature.com Read here
0 Replies | 57 Views
The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ?-NADH Binding and Voltage Gating - sciencedirect.com
Feb 18, 2024 - 12:10 AM - by nmrlearner
nmrlearner's Avatar The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ?-NADH Binding and Voltage Gating - sciencedirect.com

The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ?-NADH Binding and Voltage Gating sciencedirect.com Read here
0 Replies | 51 Views
Recent developments in deuterium solid-state NMR for the detection of slow motions in proteins - ScienceDirect
Feb 17, 2024 - 12:31 AM - by nmrlearner
nmrlearner's Avatar Recent developments in deuterium solid-state NMR for the detection of slow motions in proteins - ScienceDirect

Recent developments in deuterium solid-state NMR for the detection of slow motions in proteins ScienceDirect Read here
0 Replies | 68 Views
NMR structure of Streptomyces killer toxin-like protein, SKLP: further evidence for the wide distribution of single-domain ... - ScienceDirect
Feb 17, 2024 - 12:31 AM - by nmrlearner
nmrlearner's Avatar NMR structure of Streptomyces killer toxin-like protein, SKLP: further evidence for the wide distribution of single-domain ... - ScienceDirect

NMR structure of Streptomyces killer toxin-like protein, SKLP: further evidence for the wide distribution of single-domain ... ScienceDirect Read here
0 Replies | 52 Views
Conformation and Trimer Association of the Transmembrane Domain of the Parainfluenza Virus Fusion Protein in Lipid ... - ScienceDirect
Feb 17, 2024 - 12:31 AM - by nmrlearner
nmrlearner's Avatar Conformation and Trimer Association of the Transmembrane Domain of the Parainfluenza Virus Fusion Protein in Lipid ... - ScienceDirect

Conformation and Trimer Association of the Transmembrane Domain of the Parainfluenza Virus Fusion Protein in Lipid ... ScienceDirect Read here
0 Replies | 55 Views
The way to NMR structures of proteins - Nature.com
Feb 17, 2024 - 12:31 AM - by nmrlearner
nmrlearner's Avatar The way to NMR structures of proteins - Nature.com

The way to NMR structures of proteins Nature.com Read here
0 Replies | 80 Views
[NMR paper] Reconciling ASPP-p53 binding mode discrepancies through an ensemble binding framework that bridges crystallography and NMR data
Feb 16, 2024 - 7:14 AM - by nmrlearner
nmrlearner's Avatar Reconciling ASPP-p53 binding mode discrepancies through an ensemble binding framework that bridges crystallography and NMR data

ASPP2 and iASPP bind to p53 through their conserved ANK-SH3 domains to respectively promote and inhibit p53-dependent cell apoptosis. While crystallography has indicated that these two proteins employ distinct surfaces of their ANK-SH3 domains to bind to p53, solution NMR data has suggested similar surfaces. In this study, we employed multi-scale molecular dynamics (MD) simulations combined with free energy calculations to reconcile the discrepancy in the binding modes. We demonstrated that the...

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0 Replies | 101 Views
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