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Tiny diamond rotor could improve protein studies | MIT News ... - MIT News
May 24, 2023 - 7:58 AM - by nmrlearner
nmrlearner's Avatar Tiny diamond rotor could improve protein studies | MIT News ... - MIT News

Tiny diamond rotor could improve protein studies | MIT News ... MIT News Read here
0 Replies | 116 Views
Recently discovered protein domain regulates collagen transport - EurekAlert
May 23, 2023 - 5:05 PM - by nmrlearner
nmrlearner's Avatar Recently discovered protein domain regulates collagen transport - EurekAlert

Recently discovered protein domain regulates collagen transport EurekAlert Read here
0 Replies | 107 Views
Wheat Rust Resistance Genes Encode Unusual Proteins - Technology Networks
May 23, 2023 - 5:05 PM - by nmrlearner
nmrlearner's Avatar Wheat Rust Resistance Genes Encode Unusual Proteins - Technology Networks

Wheat Rust Resistance Genes Encode Unusual Proteins Technology Networks Read here
0 Replies | 118 Views
[NMR paper] Ranking mAb-excipient interactions in biologics formulations by NMR spectroscopy and computational approaches
May 23, 2023 - 5:05 PM - by nmrlearner
nmrlearner's Avatar Ranking mAb-excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the mechanism through direct experimental evidence of the binding affinity of an excipient to a monoclonal antibody (mAb), using saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopic method....

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0 Replies | 177 Views
Tiny Proteins May Play a Key Role in Cancer Spread - Technology Networks
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar Tiny Proteins May Play a Key Role in Cancer Spread - Technology Networks

Tiny Proteins May Play a Key Role in Cancer Spread Technology Networks Read here
0 Replies | 149 Views
3D Protein Structure Analysis Equipment Market Future Prospects ... - The Navajo Post
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar 3D Protein Structure Analysis Equipment Market Future Prospects ... - The Navajo Post

3D Protein Structure Analysis Equipment Market Future Prospects ... The Navajo Post Read here
0 Replies | 147 Views
[NMR paper] Diffusion NMR and Rheology of a Model Polymer in Bacterial Cell Lysate Crowders
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar Diffusion NMR and Rheology of a Model Polymer in Bacterial Cell Lysate Crowders

The intracellular milieu is crowded and heterogeneous, and this can have profound consequences for biomolecule motions and biochemical kinetics. Macromolecular crowding has been traditionally studied in artificial crowders like Ficoll and dextran or globular proteins such as bovine serum albumin. It is, however, not clear if the effects of artificial crowders on such phenomena are the same as the crowding that is experienced in a heterogeneous biological environment. Bacterial cells, for...

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0 Replies | 179 Views
[NMR paper] NMR Resonance Assignment of the LA Motif of Human LA-Related Protein 1
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar NMR Resonance Assignment of the LA Motif of Human LA-Related Protein 1

Human La-related protein 1 (HsLARP1) is involved in post-transcriptional regulation of certain 5' s terminal oligopyrimidine (5'TOP) mRNAs as well as other mRNAs and binds to both the 5'TOP motif and the 3'-poly(A) tail of certain mRNAs. HsLARP1 is heavily involved in cell proliferation, cell cycle defects, and cancer, where HsLARP1 is significantly upregulated in malignant cells and tissues. Like all LARPs, HsLARP1 contains a folded RNA binding domain, the La motif (LaM). Our current...

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0 Replies | 128 Views
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