Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.
 

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.

Related Articles Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.

Molecules. 2017 Aug 31;22(9):

Authors: Kim DH, Kang SM, Lee BJ

Abstract
Tuberculosis is an infectious disease caused by Mycobacteriumtuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M. tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M. tuberculosis proteins determined using NMR spectroscopy.


PMID: 28858250 [PubMed - in process]



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