BioNMR
NMR aggregator & online community since 2003
BioNMR    
Learn or help to learn NMR - get free NMR books!
 

Go Back   BioNMR > Educational resources > Journal club
Advanced Search



Jobs Groups Conferences Literature Pulse sequences Software forums Programs Sample preps Web resources BioNMR issues


Webservers
NMR processing:
MDD
NMR assignment:
Backbone:
Autoassign
MARS
UNIO Match
PINE
Side-chains:
UNIO ATNOS-Ascan
NOEs:
UNIO ATNOS-Candid
UNIO Candid
ASDP
Structure from NMR restraints:
Ab initio:
GeNMR
Cyana
XPLOR-NIH
ASDP
UNIO ATNOS-Candid
UNIO Candid
Fragment-based:
BMRB CS-Rosetta
Rosetta-NMR (Robetta)
Template-based:
GeNMR
I-TASSER
Refinement:
Amber
Structure from chemical shifts:
Fragment-based:
WeNMR CS-Rosetta
BMRB CS-Rosetta
Homology-based:
CS23D
Simshift
Torsion angles from chemical shifts:
Preditor
TALOS
Promega- Proline
Secondary structure from chemical shifts:
CSI (via RCI server)
TALOS
MICS caps, β-turns
d2D
PECAN
Flexibility from chemical shifts:
RCI
Interactions from chemical shifts:
HADDOCK
Chemical shifts re-referencing:
Shiftcor
UNIO Shiftinspector
LACS
CheckShift
RefDB
NMR model quality:
NOEs, other restraints:
PROSESS
PSVS
RPF scores
iCing
Chemical shifts:
PROSESS
CheShift2
Vasco
iCing
RDCs:
DC
Anisofit
Pseudocontact shifts:
Anisofit
Protein geomtery:
Resolution-by-Proxy
PROSESS
What-If
iCing
PSVS
MolProbity
SAVES2 or SAVES4
Vadar
Prosa
ProQ
MetaMQAPII
PSQS
Eval123D
STAN
Ramachandran Plot
Rampage
ERRAT
Verify_3D
Harmony
Quality Control Check
NMR spectrum prediction:
FANDAS
MestReS
V-NMR
Flexibility from structure:
Backbone S2
Methyl S2
B-factor
Molecular dynamics:
Gromacs
Amber
Antechamber
Chemical shifts prediction:
From structure:
Shiftx2
Sparta+
Camshift
CH3shift- Methyl
ArShift- Aromatic
ShiftS
Proshift
PPM
CheShift-2- Cα
From sequence:
Shifty
Camcoil
Poulsen_rc_CS
Disordered proteins:
MAXOCC
Format conversion & validation:
CCPN
From NMR-STAR 3.1
Validate NMR-STAR 3.1
NMR sample preparation:
Protein disorder:
DisMeta
Protein solubility:
camLILA
ccSOL
Camfold
camGroEL
Zyggregator
Isotope labeling:
UPLABEL
Solid-state NMR:
sedNMR


Reply
Thread Tools Search this Thread Rate Thread Display Modes
  #1  
Unread 09-02-2017, 02:29 AM
nmrlearner's Avatar
Senior Member
 
Join Date: Jan 2005
Posts: 20,036
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 193,617
Downloads: 0
Uploads: 0
Default Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.

Related Articles Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.

Molecules. 2017 Aug 31;22(9):

Authors: Kim DH, Kang SM, Lee BJ

Abstract
Tuberculosis is an infectious disease caused by Mycobacteriumtuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M. tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M. tuberculosis proteins determined using NMR spectroscopy.


PMID: 28858250 [PubMed - in process]



More...
Reply With Quote


Did you find this post helpful? Yes | No

Reply
Similar Threads
Thread Thread Starter Forum Replies Last Post
Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associatedwith Neutral Red Staining of Virulent Tuberculosis Strains and Homologueof the Streptomyces coelicolor Protein KbpA
Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associatedwith Neutral Red Staining of Virulent Tuberculosis Strains and Homologueof the Streptomyces coelicolor Protein KbpA http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00511/20170725/images/medium/bi-2017-00511e_0010.gif Biochemistry DOI: 10.1021/acs.biochem.7b00511 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/e01E7kEsi3k More...
nmrlearner Journal club 0 07-26-2017 10:20 AM
The PE_PGRS Proteins of Mycobacterium tuberculosis Are Ca2+ Binding Mediators of Host–Pathogen Interaction
The PE_PGRS Proteins of Mycobacterium tuberculosis Are Ca2+ Binding Mediators of Host–Pathogen Interaction http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.6b00289/20160811/images/medium/bi-2016-00289f_0009.gif Biochemistry DOI: 10.1021/acs.biochem.6b00289 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/AxnQ4TsgTgI More...
nmrlearner Journal club 0 08-11-2016 07:03 PM
[NMR paper] Solution NMR studies on Helicobacter pylori proteins for antibiotic target discovery.
Solution NMR studies on Helicobacter pylori proteins for antibiotic target discovery. Related Articles Solution NMR studies on Helicobacter pylori proteins for antibiotic target discovery. Expert Opin Drug Discov. 2016 May 23; Authors: Lee KY, Lee BJ Abstract INTRODUCTION: Helicobacter pylori (H. pylori) is a well-known widespread pathogenic bacterium that survives in the extremely acidic conditions of the human gastric mucosa. The global prevalence of H. pylori-resistant antibiotics has become an emerging issue in the 21st...
nmrlearner Journal club 0 05-25-2016 02:33 PM
Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis
Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis Source: Journal of Biomolecular NMR
nmrlearner Journal club 0 07-25-2015 01:54 PM
[NMR paper] NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review.
NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review. NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review. Molecules. 2013;18(11):13410-24 Authors: Kang SJ, Kim DH, Lee BJ Abstract Due to the widespread and increasing appearance of antibiotic resistance, a new strategy is needed for developing novel antibiotics. Especially, there are no specific antibiotics for Helicobacter pylori (H. pylori). H. pylori are bacteria that live in the stomach and are...
nmrlearner Journal club 0 11-02-2013 10:04 AM
Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis. Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1148-53 Authors: Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ Abstract Owing to the evolution of multi-drug-resistant and extremely drug-resistant Mycobacterium tuberculosis strains,...
nmrlearner Journal club 0 09-10-2011 06:51 PM
[NMR paper] NMR assignment of protein Rv1980c from Mycobacterium tuberculosis.
NMR assignment of protein Rv1980c from Mycobacterium tuberculosis. Related Articles NMR assignment of protein Rv1980c from Mycobacterium tuberculosis. J Biomol NMR. 2005 Sep;33(1):73 Authors: Danahy JM, Potter BM, Geisbrecht BV, Laity JH
nmrlearner Journal club 0 12-01-2010 06:56 PM
Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Scr
Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C. Related Articles Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C. J Med Chem. 2010 Nov 12; Authors: Scheich C, Puetter V, Schade M Protein target-based discovery of novel antibiotics has been largely unsuccessful despite rich genome information. Particularly in need are new antibiotics for tuberculosis, which kills 1.6 million people annually and shows a rapid increase in...
nmrlearner Journal club 0 11-16-2010 04:13 PM


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes Rate This Thread
Rate This Thread:

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On
Trackbacks are Off
Pingbacks are Off
Refbacks are Off



BioNMR advertisements to pay for website hosting and domain registration. Nobody does it for us.



Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
Copyright, BioNMR.com, 2003-2013
Search Engine Friendly URLs by vBSEO 3.6.0

All times are GMT. The time now is 11:17 PM.


Map