Probing transient non-native states in amyloid beta fiber elongation by NMR.
Probing transient non-native states in amyloid beta fiber elongation by NMR.
http://www.bionmr.com//www.ncbi.nlm...._z_RSClogo.gif Related Articles Probing transient non-native states in amyloid beta fiber elongation by NMR. Chem Commun (Camb). 2019 Apr 11;55(31):4483-4486 Authors: Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A Abstract Using NMR to probe transient binding of A?1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design. PMID: 30917192 [PubMed - indexed for MEDLINE] More... |
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