Trinucleotide repeat (TNR) diseases are caused by the aberrant expansion of CXG (X = C, A, G and T) sequences in genomes. We have reported two small molecules binding to TNR, NCD, and NA, which strongly bind to CGG repeat (responsible sequence of fragile X syndrome) and CAG repeat (Huntington's disease). The NMR structure of NA binding to the CAG/CAG triad has been clarified, but the structure of NCD bound to the CGG/CGG triad remained to be addressed. We here report the structural determination...
Periplasmic Binding Protein Dimer Has a Second AllostericEvent Tied to Ligand Binding
Periplasmic Binding Protein Dimer Has a Second AllostericEvent Tied to Ligand Binding
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00657/20170922/images/medium/bi-2017-00657x_0006.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00657
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/kcJzvDujZt8
More...
nmrlearner
Journal club
0
09-23-2017 05:52 AM
Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)
Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00148/20170710/images/medium/bi-2017-00148s_0009.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00148
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/SyXct7vdHtA
More...
nmrlearner
Journal club
0
07-11-2017 09:20 AM
[NMR paper] Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions.
Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-highwire.gif http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates...
[NMR paper] Screening protein - single stranded RNA complexes by NMR spectroscopy for structure determination.
Screening protein - single stranded RNA complexes by NMR spectroscopy for structure determination.
Screening protein - single stranded RNA complexes by NMR spectroscopy for structure determination.
Methods. 2013 Oct 1;
Authors: Foot JN, Feracci M, Dominguez C
Abstract
In the past few years, RNA molecules have been revealed to be at the center of numerous biological processes. Long considered as passive molecules transferring genetic information from DNA to proteins, it is now well established that RNA molecules play important regulatory...
nmrlearner
Journal club
0
10-08-2013 02:04 PM
Screening protein – single stranded RNA complexes by NMR spectroscopy for structure determination
Screening protein – single stranded RNA complexes by NMR spectroscopy for structure determination
Publication date: Available online 1 October 2013
Source:Methods</br>
Author(s): Jaelle N. Foot , Mikael Feracci , Cyril Dominguez</br>
In the past few years, RNA molecules have been revealed to be at the center of numerous biological processes. Long considered as passive molecules transferring genetic information from DNA to proteins, it is now well established that RNA molecules play important regulatory roles. Associated with that, the number of identified RNA...
nmrlearner
Journal club
0
10-01-2013 11:15 PM
[NMR images] NMR structure of the double stranded RNA binding domain of EIF2AK2 ...
http://upload.wikimedia.org/wikipedia/en/thumb/2/27/PBB_Protein_EIF2AK2_image.jpg/250px-PBB_Protein_EIF2AK2_image.jpg
en.wikipedia.org
19/07/2013 7:44:28 AM GMT
NMR structure of the double stranded RNA binding domain of EIF2AK2 ...
More...
nmrlearner
NMR pictures
0
07-19-2013 07:43 AM
[NMR paper] Detection of the water-binding sites of the oxygen-evolving complex of Photosystem II using W-band 17O electron-electron double resonance-detected NMR spectroscopy.
Detection of the water-binding sites of the oxygen-evolving complex of Photosystem II using W-band 17O electron-electron double resonance-detected NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Detection of the water-binding sites of the oxygen-evolving complex of Photosystem II using W-band 17O electron-electron double resonance-detected NMR spectroscopy.
J Am Chem Soc. 2012 Oct 10;134(40):16619-34
Authors: Rapatskiy L, Cox N, Savitsky A, Ames WM, Sander J,...
NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA
Threaded Mode