Thread: NMR paper Conformational changes in the human estrogen receptor observed by (19)F NMR.
View Single Post
  #1  
Unread 11-18-2010, 09:15 PM
nmrlearner's Avatar
nmrlearner nmrlearner is offline
Senior Member
  
Join Date: Jan 2005
Posts: 23,192
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 0
Downloads: 0
Uploads: 0
Default Conformational changes in the human estrogen receptor observed by (19)F NMR.
Conformational changes in the human estrogen receptor observed by (19)F NMR.

Related Articles Conformational changes in the human estrogen receptor observed by (19)F NMR.

Biochem Biophys Res Commun. 2000 Apr 21;270(3):988-91

Authors: Luck LA, Barse JL, Luck AM, Peck CH

The (19)F NMR spectra of the 5F-Trp labeled glutathione-S-transferase fusion protein with residues 282-595 of the human estrogen receptor show that there is a distinct conformational change in the protein when estradiol is added to the unliganded protein. Our studies show the empty receptor to have more conformational flexibility than the liganded form. This study shows the applicability of (19)F NMR to study conformational change in large protein systems.

PMID: 10772938 [PubMed - indexed for MEDLINE]



Source: PubMed
Reply With Quote

Did you find this post helpful? Yes | No