Thread: NMR paper An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi-domain protein
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Unread 08-26-2023, 09:35 PM
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Default An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi-domain protein
An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi-domain protein

Cyclization can stabilize the structure of proteins, as previously demonstrated in single-domain proteins. Although Lys48-linked polyubiquitin, a multi-domain protein, is also known to be cyclized in human cells, the structural effects of cyclization remain unclear. Here, we examined the impact of cyclization on the structural stability and dynamics of cyclic Lys48-linked diubiquitin (Ub(2) ). As expected, cyclization increased the thermal stability of Ub(2) and its resistance to proteolytic...

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