Unambiguous identification of ?-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy
The ?-Gal epitope consisting of the terminal trisaccharide Gal?1,3Gal?1,4GlcNAc exposed on cell or protein surfaces can cause severe immune reactions, such as hypersensitivity reactions, in humans. This epitope is also called the xenotransplantation epitope because it is one of the main reasons for the rejection of non-human organ transplants by the human innate immune response. Recombinant therapeutic proteins expressed in murine cell lines may contain ?-Gal epitopes, and therefore their...
More...