Thread: NMR paper In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide
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Unread 09-26-2022, 02:08 AM
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Default In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide
In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide

Dynamic nuclear polarization NMR spectroscopy was used to investigate the effect of the antimicrobial peptide (AMP) maculatin 1.1 on E. coli cells. The enhanced ^(15)N NMR signals from nucleic acids, proteins and lipids identified a number of unanticipated physiological responses to peptide stress, revealing that membrane-active AMPs can have a multi-target impact on E. coli cells. DNP-enhanced ^(15)N-observed ^(31)P-dephased REDOR NMR allowed monitoring how Mac1 induced DNA condensation and...

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