Thread: NMR paper NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF
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Default NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF
NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF

Structure-function relationships in proteins refer to a trade-off between stability and bioactivity, molded by evolution of the molecule. Identifying which protein amino acid residues jeopardize global or local stability for the benefit of bioactivity would reveal residues pivotal to this structure-function trade-off. Here, we use ^(15)N-¹H heteronuclear single quantum coherence (HSQC) nuclear magnetic resonance (NMR) spectroscopy to probe the microenvironment and dynamics of residues in...

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