Analysis of Global and Residue-Specific yB Crystallin Protein Dynamics via NMR Spectroscopy and Dynamic Light Scattering
The proteins that comprise the water-soluble interior of the optic lens are referred to as crystallin proteins, of which three major categories have been identified: alpha (a), beta (b), and gamma (y). Gamma and beta crystallin proteins have been observed to undergo aggregation and phase-separation over time, which can lead to the formation of cataracts, while alpha crystallin limits this formation by removing deformed protein aggregates from solution. Here, we describe our studies on bovine yB...
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