Thread: NMR paper Dynamics and Mechanistic Underpinnings to Pharmacology of Class A GPCRs - An NMR Perspective
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Unread 03-05-2022, 01:44 AM
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Default Dynamics and Mechanistic Underpinnings to Pharmacology of Class A GPCRs - An NMR Perspective
Dynamics and Mechanistic Underpinnings to Pharmacology of Class A GPCRs - An NMR Perspective

One-third of current pharmaceuticals target G protein-coupled receptors (GPCRs), the largest receptor superfamily in humans and mediators of diverse physiological processes. This review summarizes the recent progress in GPCR structural dynamics, focusing on class A receptors and insights derived from nuclear magnetic resonance (NMR) and other spectroscopic techniques. We describe the structural aspects of GPCR activation and the various pharmacological models that capture aspects of receptor...

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