Thread: NMR paper Solution NMR backbone assignments of the N-terminal Zalpha-linker-Zbeta segment from Homo sapiens ADAR1p150
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Unread 03-21-2021, 01:33 PM
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Default Solution NMR backbone assignments of the N-terminal Zalpha-linker-Zbeta segment from Homo sapiens ADAR1p150
Solution NMR backbone assignments of the N-terminal Zalpha-linker-Zbeta segment from Homo sapiens ADAR1p150

Adenosine-to-inosine (A-to-I) editing of a subset of RNAs in a eukaryotic cell is required in order to avoid triggering the innate immune system. Editing is carried out by ADAR1, which exists as short (p110) and long (p150) isoforms. ADAR1p150 is mostly cytoplasmic, possesses a Z-RNA binding domain (Z?), and is only expressed during the innate immune response. A structurally homologous domain to Z?, the Z? domain, is separated by a long linker from Z? on the N-terminus of ADAR1 but its function...

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