Thread: Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR [Biophysics and Computational Biology]
View Single Post
  #1  
Unread 03-11-2021, 06:03 AM
nmrlearner's Avatar
nmrlearner nmrlearner is offline
Senior Member
  
Join Date: Jan 2005
Posts: 23,207
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 0
Downloads: 0
Uploads: 0
Default Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR [Biophysics and Computational Biology]
Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR [Biophysics and Computational Biology]

Yuki Toyama, Robert W. Harkness, Tim Y. T. Lee, Jason T. Maynes, Lewis E. Kay...
Date: 2021-03-10

Human High temperature requirement A2 (HtrA2) is a mitochondrial protease chaperone that plays an important role in cellular proteostasis and in regulating cell-signaling events, with aberrant HtrA2 function leading to neurodegeneration and parkinsonian phenotypes. Structural studies of the enzyme have established a trimeric architecture, comprising three identical protomers in which... Read More


PNAS:
Number: 11
Volume: 118
Reply With Quote

Did you find this post helpful? Yes | No