Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.
Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.
Chem Commun (Camb). 2018 Mar 21;:
Authors: Ward ME, Daniëls MA, van Kappel EC, Maurice MM, Baldus M
Abstract
We report solid-state Nuclear Magnetic Resonance (ssNMR) studies on amyloid-like protein complexes formed by DIX domains that mediate key protein interactions in the Wnt signalling pathway. Our results provide insight into the 3D fold of the self-associated Axin-DIX domain and identify a potential lipid cofactor.
PMID: 29561051 [PubMed - as supplied by publisher]
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