Thread: NMR paper FT-IR and NMR structural markers for thiazole-based ?-peptide foldamers.
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Default FT-IR and NMR structural markers for thiazole-based ?-peptide foldamers.
FT-IR and NMR structural markers for thiazole-based ?-peptide foldamers.

Related Articles FT-IR and NMR structural markers for thiazole-based ?-peptide foldamers.

Org Biomol Chem. 2016 Sep 21;14(37):8664-8669

Authors: Bonnel C, Legrand B, Bantignies JL, Petitjean H, Martinez J, Masurier N, Maillard LT

Abstract
Nuclear magnetic resonance (NMR) spectroscopy has been established as a potent method for the determination of foldamer structures in solution. However, the NMR techniques could be limited by averaging, so additional experimental techniques are often needed to fully endorse the folding properties of a sequence. We have recently demonstrated that oligo-?-peptides composed of 4-amino(methyl)-1,3-thiazole-5-carboxylic acids (ATCs) adopt an original helical fold stabilized by hydrogen bonds forming C9 pseudocycles. The main objective of the present work is to reinvestigate the folding of ATC oligomer 1 in order to identify reliable FT-IR and NMR structural markers that are of value for tracking the degree of organization of ATC-based peptides.


PMID: 27714174 [PubMed - indexed for MEDLINE]



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