NOAH: NMR Supersequences for Small Molecule Analysis and Structure Elucidation
Nested NMR experiments combining up to five conventional NMR pulse sequences into one supersequence are introduced. The core 2D NMR techniques routinely employed in small molecule NMR spectroscopy, such as HSQC, HMQC, HMBC, COSY, NOESY, TOCSY, and similar, can be recorded in a single measurement. In this way the data collection time may be dramatically reduced and sample throughput increased for basic NMR applications, such as structure elucidation and verification in synthetic, medicinal, and natural product chemistry.NOAH's Ark: The nesting of up to five conventional NMR pulse sequences into one “NOAH supersequence”, employing only a single recovery delay, saves a significant amount of time during data collection for the analysis of small molecules. These experiments do not require specialist spectrometer hardware.
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