NMR backbone resonance assignment of New Delhi metallo-beta-lactamase.
Related Articles NMR backbone resonance assignment of New Delhi metallo-beta-lactamase.
Biomol NMR Assign. 2017 Aug 14;:
Authors: Yao C, Wu Q, Xu G, Li C
Abstract
The emerging of the New Delhi metallo-beta-lactamase (NDM-1) has become one of the greatest threats to the clinical treatment. Although the structure of NDM-1 has been determined by X-ray crystallography, the molecular mechanism and process of catalysis reaction remain elusive. NMR spectroscopy plays a unique role in the characterization of conformational dynamics. Here we report the backbone (1)H, (15)N and (13)C chemical shift assignments of NDM-1 by heteronuclear multidimensional NMR spectroscopy as well as its secondary structure in solution as predicted by TALOS+.
PMID: 28808891 [PubMed - as supplied by publisher]
More...