What are the biggest differences in solving NMR structures of DNA or RNA vs. proteins?
I've only solved NMR structure of globular proteins (actually in a complex with a short stretch of DNA), but never a structure of nucleic acid alone.
What are (are there?) the major differences in the approaches when working on a structure of nucleic acid - in terms of choice of the NMR technique, maybe specific parameters and structure simulation?
Are distance restraints alone sufficient to obtain structure of DNA or RNA?
Thank you in advance!
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