Thread: Nanoemulsion Contrast Agents with Sub-picomolar Sensitivity for Xenon NMR
View Single Post
  #1  
Unread 11-21-2013, 01:14 AM
nmrlearner's Avatar
nmrlearner nmrlearner is offline
Senior Member
  
Join Date: Jan 2005
Posts: 23,210
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 0
Downloads: 0
Uploads: 0
Default Nanoemulsion Contrast Agents with Sub-picomolar Sensitivity for Xenon NMR
From The DNP-NMR Blog:

Nanoemulsion Contrast Agents with Sub-picomolar Sensitivity for Xenon NMR


Stevens, T.K., R.M. Ramirez, and A. Pines, Nanoemulsion Contrast Agents with Sub-picomolar Sensitivity for Xenon NMR. J. Am. Chem. Soc., 2013. 135(26): p. 9576-9579.


http://dx.doi.org/10.1021/ja402885q


<div style="text-align: justify;">A new type of contrast agent for Xe NMR based on surfactant-stabilized perfluorocarbon-in-water nanoemulsions has been produced. The contrast agent uses dissolved hyperpolarized xenon gas as a nonperturbing reporting medium, as xenon freely exchanges between aqueous solution and the perfluorocarbon interior of the droplets, which are spectroscopically distinguishable and allow for chemical exchange saturation transfer (CEST) detection of the agent. Nanoemulsions with droplet diameters between 160 and 310 nm were produced and characterized using hyperpolarized 129Xe combined with CEST detection. Saturation parameters were varied and data were modeled numerically to determine the xenon exchange dynamics of the system. Nanoemulsion droplets were detected at concentrations as low as 100 fM, corresponding to
Reply With Quote

Did you find this post helpful? Yes | No