NASR, An Effective Approach for Simultaneous Noise and Artifact Suppression in NMR Spectroscopy.
Related Articles NASR, An Effective Approach for Simultaneous Noise and Artifact Suppression in NMR Spectroscopy.
Anal Chem. 2013 Jan 22;
Authors: Jiang B, Luo F, Ding Y, Sun P, Zhang X, Jiang L, Li C, Mao XA, Yang D, Tang C, Liu M
Abstract
As a powerful tool for biological analysis, especially protein structure and dynamic studies, nuclear magnetic resonance (NMR) spectroscopy suffers from intrinsic low signal to nose ratio (SNR) and long acquisition time required for multidimensional (nD) experiments. Non-uniform sampling (NUS) can effectively speed up the experiment, but often introduces artifacts into spectrum. In addition to development of high sensitive hardwares and NMR pulse sequences, data post-processing is a relative simple and cost-effective method to improve the SNR and suppress the artifacts. In this work, we proposed an effective approach for simultaneously suppressing noise and artifacts based on the resampling principle The method is named NASR for short and tested using one-, two- and three-dimensional (1D, 2D & 3D) NMR spectra that were acquired using ether conventional or NUS (spiral and random, for 3D) approaches. The results reveal that the NASR is fast and applicable for improving the quality of 1D to nD NMR spectra with all kind of sampling schemes.
PMID: 23339579 [PubMed - as supplied by publisher]
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