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Default Investigation of ligand-receptor systems by high-resolution solid-state NMR: recent p

Investigation of ligand-receptor systems by high-resolution solid-state NMR: recent progress and perspectives.

Related Articles Investigation of ligand-receptor systems by high-resolution solid-state NMR: recent progress and perspectives.

Arch Pharm (Weinheim). 2005 Jun;338(5-6):217-28

Authors: Luca S, Heise H, Lange A, Baldus M

Solid-state Nuclear Magnetic Resonance (NMR) provides a general method to study molecular structure and dynamics in a non-crystalline and insoluble environment. We discuss the latest methodological progress to construct 3D molecular structures from solid-state NMR data obtained under magic-angle-spinning conditions. As shown for the neurotensin/NTS-1 system, these methods can be readily applied to the investigation of ligand-binding to G-protein coupled receptors.

PMID: 15938000 [PubMed - indexed for MEDLINE]



Source: PubMed
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