Thread: NMR paper The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors
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Default The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors
The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors.

Related Articles The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors.

Curr Top Med Chem. 2004;4(12):1311-27

Authors: Rush TS, Powers R

The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFalpha-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.

PMID: 15320728 [PubMed - indexed for MEDLINE]



Source: PubMed
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